Increased risk of colorectal cancer among patients with biliary tract inflammation: A 5-year follow-up study

Hsiu Li Lin, Hsiu Chen Lin, Ching Chun Lin, Herng Ching Lin

研究成果: 雜誌貢獻文章同行評審

9 引文 斯高帕斯(Scopus)

摘要

The purpose of the study was to investigate the risk of colorectal cancer among patients with biliary tract inflammation (BTI) compared to non-BTI patients during a 5-year follow-up period. The study group comprised 1,613 patients with BTI, among which 32 cases (1.98%) developed colorectal cancer. The comparison group included 8,065 randomly selected subjects (5 for every patient with BTI), 74 of whom contracted colorectal cancer (0.92%). Stratified Cox proportional hazard regressions were calculated to estimate the adjusted hazard of colorectal cancer between the study group and comparison group. The adjusted hazard ratio for colorectal cancer for patients with BTI was 6.54 times (95% CI = 3.07-13.92) as high as for those without BTI within a 1-year follow-up period, 3.20 times (95% CI = 1.93-5.30) as high within a 3-year follow-up period, and 2.21 times (95% CI = 1.45-3.37) as high within a 5-year follow-up period. We also found that the adjusted hazard ratio for colorectal cancer for those with bile duct inflammation was 3.30 times (95% CI = 1.87-5.84) as high as for those without BTI within the 5-year follow-up period. However, no increased hazard of colorectal cancer was observed for patients with gallbladder inflammation. We concluded that patients with BTI had a significantly higher risk of colorectal cancer compared to patients without BTI.
原文英語
頁(從 - 到)447-452
頁數6
期刊International Journal of Cancer
128
發行號2
DOIs
出版狀態已發佈 - 一月 15 2011

ASJC Scopus subject areas

  • 癌症研究
  • 腫瘤科

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