摘要
Background:Profound alterations in immune responses associated with uremia and exacerbated by dialysis increase the risk of active tuberculosis (TB). Evidence of the long-term risk and outcome of active TB after acute kidney injury (AKI) is limited.Methods:This population-based-cohort study used claim records retrieved from the Taiwan National Health Insurance database. We retrieved records of all hospitalized patients, more than 18 years, who underwent dialysis for acute kidney injury (AKI) during 1999-2008 and validated using the NSARF data. Time-dependent Cox proportional hazards model to adjust for the ongoing effect of end-stage renal disease (ESRD) was conducted to predict long-term de novo active TB after discharge from index hospitalization.Results:Out of 2,909 AKI dialysis patients surviving 90 days after index discharge, 686 did not require dialysis after hospital discharge. The control group included 11,636 hospital patients without AKI, dialysis, or history of TB. The relative risk of active TB in AKI dialysis patients, relative to the general population, after a mean follow-up period of 3.6 years was 7.71. Patients who did (hazard ratio [HR], 3.84; p
| 原文 | 英語 |
|---|---|
| 文章編號 | e69556 |
| 期刊 | PLoS One |
| 卷 | 8 |
| 發行號 | 7 |
| DOIs | |
| 出版狀態 | 已發佈 - 七月 25 2013 |
| 對外發佈 | Yes |
指紋
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
引用此文
Increased Risk of Active Tuberculosis following Acute Kidney Injury : A Nationwide, Population-Based Study. / Wu, Vin Cent; Wang, Chen Yi; Shiao, Chih Chung; Chang, Chia Hsui; Huang, Hui Yu; Huang, Tao Min; Lai, Chun Fu; Lin, Meng Chun; Ko, Wen Je; Wu, Kwan Dun; Yu, Chong Jen; Shu, Chin Chung; Lee, Chih Hsin; Wang, Jann Yuan.
於: PLoS One, 卷 8, 編號 7, e69556, 25.07.2013.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Increased Risk of Active Tuberculosis following Acute Kidney Injury
T2 - A Nationwide, Population-Based Study
AU - Wu, Vin Cent
AU - Wang, Chen Yi
AU - Shiao, Chih Chung
AU - Chang, Chia Hsui
AU - Huang, Hui Yu
AU - Huang, Tao Min
AU - Lai, Chun Fu
AU - Lin, Meng Chun
AU - Ko, Wen Je
AU - Wu, Kwan Dun
AU - Yu, Chong Jen
AU - Shu, Chin Chung
AU - Lee, Chih Hsin
AU - Wang, Jann Yuan
PY - 2013/7/25
Y1 - 2013/7/25
N2 - Background:Profound alterations in immune responses associated with uremia and exacerbated by dialysis increase the risk of active tuberculosis (TB). Evidence of the long-term risk and outcome of active TB after acute kidney injury (AKI) is limited.Methods:This population-based-cohort study used claim records retrieved from the Taiwan National Health Insurance database. We retrieved records of all hospitalized patients, more than 18 years, who underwent dialysis for acute kidney injury (AKI) during 1999-2008 and validated using the NSARF data. Time-dependent Cox proportional hazards model to adjust for the ongoing effect of end-stage renal disease (ESRD) was conducted to predict long-term de novo active TB after discharge from index hospitalization.Results:Out of 2,909 AKI dialysis patients surviving 90 days after index discharge, 686 did not require dialysis after hospital discharge. The control group included 11,636 hospital patients without AKI, dialysis, or history of TB. The relative risk of active TB in AKI dialysis patients, relative to the general population, after a mean follow-up period of 3.6 years was 7.71. Patients who did (hazard ratio [HR], 3.84; p
AB - Background:Profound alterations in immune responses associated with uremia and exacerbated by dialysis increase the risk of active tuberculosis (TB). Evidence of the long-term risk and outcome of active TB after acute kidney injury (AKI) is limited.Methods:This population-based-cohort study used claim records retrieved from the Taiwan National Health Insurance database. We retrieved records of all hospitalized patients, more than 18 years, who underwent dialysis for acute kidney injury (AKI) during 1999-2008 and validated using the NSARF data. Time-dependent Cox proportional hazards model to adjust for the ongoing effect of end-stage renal disease (ESRD) was conducted to predict long-term de novo active TB after discharge from index hospitalization.Results:Out of 2,909 AKI dialysis patients surviving 90 days after index discharge, 686 did not require dialysis after hospital discharge. The control group included 11,636 hospital patients without AKI, dialysis, or history of TB. The relative risk of active TB in AKI dialysis patients, relative to the general population, after a mean follow-up period of 3.6 years was 7.71. Patients who did (hazard ratio [HR], 3.84; p
UR - http://www.scopus.com/inward/record.url?scp=84880814793&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880814793&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0069556
DO - 10.1371/journal.pone.0069556
M3 - Article
VL - 8
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 7
M1 - e69556
ER -