Increased risk for cancer following erectile dysfunction: A nationwide population-based follow-up study

Shiu Dong Chung, Jiunn Horng Kang, Chun Hou Liao, Kuan Ming Chiu, Herng Ching Lin

研究成果: 雜誌貢獻文章

17 引文 (Scopus)

摘要

Introduction. Previous studies have suggested that erectile dysfunction (ED) is associated with chronic inflammation, which is also a principle mechanism of carcinogensis. However, very few studies have attempted to examine the association between ED and subsequent cancer. Aim. Using a nationwide population-based data set, the aim of this study is to investigate the risk for cancer during a 5-year follow-up period after a diagnosis of ED, compared to patients without ED during the same period, while adjusting for socio-demographic characteristics. Main Outcome Measure. Stratified Cox proportional hazard regression was performed to compare the 5-year cancer-free survival rate for the two cohorts. Methods. This study used data sourced from the Taiwan "Longitudinal Health Insurance Database." The study cohort comprised 1,882 patients with ED and 9,410 randomly selected subjects as the comparison cohort. Each patient was then individually tracked for 5 years from their index ambulatory care visit to identify those who had diagnosed episodes of cancer. Results. Of the sampled patients, 183 (1.6%) had cancer within the 5-year follow-up period, that is, 43 individuals (2.3% of the patients with ED) from the study cohort and 140 individuals (1.6% of patients in the comparison cohort) from the comparison cohort. After adjusting for the patients' monthly income, the geographic location and urbanization level of the community in which the patient resided, hypertension, diabetes, coronary heart disease, and hyperlipidemia, regression analysis reveals that the hazard of having cancer during the 5-year follow-up period was 1.42 (95% CI=1.03-2.09, P=0.039) times greater for patients with ED than comparison patients. However, data on smoking, which is an important factor in ED and cancer, is not available and remains a potential confounder. Conclusions. We conclude that the incidence of cancer in the 5 years after an ED diagnosis is significantly higher than in the general population.
原文英語
頁(從 - 到)1513-1520
頁數8
期刊Journal of Sexual Medicine
8
發行號5
DOIs
出版狀態已發佈 - 五月 2011

指紋

Erectile Dysfunction
Population
Neoplasms
Cohort Studies
Geographic Locations
Urbanization
Health Insurance
Ambulatory Care
Hyperlipidemias
Taiwan
Coronary Disease
Survival Rate
Smoking
Regression Analysis
Demography
Outcome Assessment (Health Care)
Databases
Hypertension
Inflammation
Incidence

ASJC Scopus subject areas

  • Urology
  • Obstetrics and Gynaecology
  • Reproductive Medicine

引用此文

Increased risk for cancer following erectile dysfunction : A nationwide population-based follow-up study. / Chung, Shiu Dong; Kang, Jiunn Horng; Liao, Chun Hou; Chiu, Kuan Ming; Lin, Herng Ching.

於: Journal of Sexual Medicine, 卷 8, 編號 5, 05.2011, p. 1513-1520.

研究成果: 雜誌貢獻文章

@article{29369ac367cb43be9c9768b936a3ba5d,
title = "Increased risk for cancer following erectile dysfunction: A nationwide population-based follow-up study",
abstract = "Introduction. Previous studies have suggested that erectile dysfunction (ED) is associated with chronic inflammation, which is also a principle mechanism of carcinogensis. However, very few studies have attempted to examine the association between ED and subsequent cancer. Aim. Using a nationwide population-based data set, the aim of this study is to investigate the risk for cancer during a 5-year follow-up period after a diagnosis of ED, compared to patients without ED during the same period, while adjusting for socio-demographic characteristics. Main Outcome Measure. Stratified Cox proportional hazard regression was performed to compare the 5-year cancer-free survival rate for the two cohorts. Methods. This study used data sourced from the Taiwan {"}Longitudinal Health Insurance Database.{"} The study cohort comprised 1,882 patients with ED and 9,410 randomly selected subjects as the comparison cohort. Each patient was then individually tracked for 5 years from their index ambulatory care visit to identify those who had diagnosed episodes of cancer. Results. Of the sampled patients, 183 (1.6{\%}) had cancer within the 5-year follow-up period, that is, 43 individuals (2.3{\%} of the patients with ED) from the study cohort and 140 individuals (1.6{\%} of patients in the comparison cohort) from the comparison cohort. After adjusting for the patients' monthly income, the geographic location and urbanization level of the community in which the patient resided, hypertension, diabetes, coronary heart disease, and hyperlipidemia, regression analysis reveals that the hazard of having cancer during the 5-year follow-up period was 1.42 (95{\%} CI=1.03-2.09, P=0.039) times greater for patients with ED than comparison patients. However, data on smoking, which is an important factor in ED and cancer, is not available and remains a potential confounder. Conclusions. We conclude that the incidence of cancer in the 5 years after an ED diagnosis is significantly higher than in the general population.",
keywords = "Cancer, Epidemiology, Erectile Dsyfunction and Chronic Inflammation, Erectile Dysfunction",
author = "Chung, {Shiu Dong} and Kang, {Jiunn Horng} and Liao, {Chun Hou} and Chiu, {Kuan Ming} and Lin, {Herng Ching}",
year = "2011",
month = "5",
doi = "10.1111/j.1743-6109.2010.02076.x",
language = "English",
volume = "8",
pages = "1513--1520",
journal = "Journal of Sexual Medicine",
issn = "1743-6095",
publisher = "Blackwell Publishing Ltd",
number = "5",

}

TY - JOUR

T1 - Increased risk for cancer following erectile dysfunction

T2 - A nationwide population-based follow-up study

AU - Chung, Shiu Dong

AU - Kang, Jiunn Horng

AU - Liao, Chun Hou

AU - Chiu, Kuan Ming

AU - Lin, Herng Ching

PY - 2011/5

Y1 - 2011/5

N2 - Introduction. Previous studies have suggested that erectile dysfunction (ED) is associated with chronic inflammation, which is also a principle mechanism of carcinogensis. However, very few studies have attempted to examine the association between ED and subsequent cancer. Aim. Using a nationwide population-based data set, the aim of this study is to investigate the risk for cancer during a 5-year follow-up period after a diagnosis of ED, compared to patients without ED during the same period, while adjusting for socio-demographic characteristics. Main Outcome Measure. Stratified Cox proportional hazard regression was performed to compare the 5-year cancer-free survival rate for the two cohorts. Methods. This study used data sourced from the Taiwan "Longitudinal Health Insurance Database." The study cohort comprised 1,882 patients with ED and 9,410 randomly selected subjects as the comparison cohort. Each patient was then individually tracked for 5 years from their index ambulatory care visit to identify those who had diagnosed episodes of cancer. Results. Of the sampled patients, 183 (1.6%) had cancer within the 5-year follow-up period, that is, 43 individuals (2.3% of the patients with ED) from the study cohort and 140 individuals (1.6% of patients in the comparison cohort) from the comparison cohort. After adjusting for the patients' monthly income, the geographic location and urbanization level of the community in which the patient resided, hypertension, diabetes, coronary heart disease, and hyperlipidemia, regression analysis reveals that the hazard of having cancer during the 5-year follow-up period was 1.42 (95% CI=1.03-2.09, P=0.039) times greater for patients with ED than comparison patients. However, data on smoking, which is an important factor in ED and cancer, is not available and remains a potential confounder. Conclusions. We conclude that the incidence of cancer in the 5 years after an ED diagnosis is significantly higher than in the general population.

AB - Introduction. Previous studies have suggested that erectile dysfunction (ED) is associated with chronic inflammation, which is also a principle mechanism of carcinogensis. However, very few studies have attempted to examine the association between ED and subsequent cancer. Aim. Using a nationwide population-based data set, the aim of this study is to investigate the risk for cancer during a 5-year follow-up period after a diagnosis of ED, compared to patients without ED during the same period, while adjusting for socio-demographic characteristics. Main Outcome Measure. Stratified Cox proportional hazard regression was performed to compare the 5-year cancer-free survival rate for the two cohorts. Methods. This study used data sourced from the Taiwan "Longitudinal Health Insurance Database." The study cohort comprised 1,882 patients with ED and 9,410 randomly selected subjects as the comparison cohort. Each patient was then individually tracked for 5 years from their index ambulatory care visit to identify those who had diagnosed episodes of cancer. Results. Of the sampled patients, 183 (1.6%) had cancer within the 5-year follow-up period, that is, 43 individuals (2.3% of the patients with ED) from the study cohort and 140 individuals (1.6% of patients in the comparison cohort) from the comparison cohort. After adjusting for the patients' monthly income, the geographic location and urbanization level of the community in which the patient resided, hypertension, diabetes, coronary heart disease, and hyperlipidemia, regression analysis reveals that the hazard of having cancer during the 5-year follow-up period was 1.42 (95% CI=1.03-2.09, P=0.039) times greater for patients with ED than comparison patients. However, data on smoking, which is an important factor in ED and cancer, is not available and remains a potential confounder. Conclusions. We conclude that the incidence of cancer in the 5 years after an ED diagnosis is significantly higher than in the general population.

KW - Cancer

KW - Epidemiology

KW - Erectile Dsyfunction and Chronic Inflammation

KW - Erectile Dysfunction

UR - http://www.scopus.com/inward/record.url?scp=79955128046&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955128046&partnerID=8YFLogxK

U2 - 10.1111/j.1743-6109.2010.02076.x

DO - 10.1111/j.1743-6109.2010.02076.x

M3 - Article

C2 - 20955312

AN - SCOPUS:79955128046

VL - 8

SP - 1513

EP - 1520

JO - Journal of Sexual Medicine

JF - Journal of Sexual Medicine

SN - 1743-6095

IS - 5

ER -