Increased plasma levels of urokinase plasminogen activator and matrix metalloproteinase-9 in nonsmall cell lung cancer patients

Shun F. Yang, Yih Shou Hsieh, Chiao L. Lin, Nan Yung Hsu, Hui Ling Chiou, Fen P. Chou, Shu Chen Chu

研究成果: 雜誌貢獻文章同行評審

67 引文 斯高帕斯(Scopus)

摘要

Background: The involvements of matrix metalloproteinase-9 (MMP-9) and urokinase plasminogen activator (uPA) in the pathogenesis of various types of lung cancers have been established. The aim of the present study was to determine the concentrations of MMP-9 and uPA in the plasma of nonsmall cell lung cancer (NSCLC) patients. Methods: Gelatin zymography and ELISA were used to measure MMP-9 and uPA concentrations, respectively, in 90 NSCLC patients and 50 control subjects. Results: Compared with that of control subjects, MMP-9 and uPA levels were significantly higher in the plasma of NSCLC patients (P<0.001 and P<0.01, respectively). Further statistical analysis for clinic pathological parameters revealed that MMP-9 and uPA levels were significantly increased in patients with metastasis (P<0.01 and P<0.05, respectively). Furthermore, the MMP-9 level was significantly different between smokers and nonsmokers (P<0.05) while uPA levels varied between histological types (P<0.05). Conclusions: Plasma MMP-9 and uPA might play an important role in the metastasis of NSCLC by involvement in the processes of invasion and metastasis. © 2004 Elsevier B.V. All rights reserved.
原文英語
頁(從 - 到)91-99
頁數9
期刊Clinica Chimica Acta
354
發行號1-2
DOIs
出版狀態已發佈 - 4月 2005
對外發佈

ASJC Scopus subject areas

  • 生物化學
  • 臨床生物化學

指紋

深入研究「Increased plasma levels of urokinase plasminogen activator and matrix metalloproteinase-9 in nonsmall cell lung cancer patients」主題。共同形成了獨特的指紋。

引用此