Increased numbers of foxp3-positive regulatory T cells in gastritis, peptic ulcer and gastric adenocarcinoma

Hsin Hung Cheng, Guan Ying Tseng, Hsiao Bai Yang, Hung Jung Wang, Hwai Jeng Lin, Wen Ching Wang

研究成果: 雜誌貢獻文章同行評審

34 引文 斯高帕斯(Scopus)

摘要

AIM: To determine the number of regulatory T cells (Tregs) in gastric mucosa of patients with gastritis, peptic ulcers and gastric cancer. METHODS: This study was a retrospective analysis of gastric antrum biopsy specimens from healthy controls (n = 22) and patients with gastritis (n = 30), peptic ulcer (n = 83), or gastric cancer (n = 32). Expression of CD4, CD25 and Foxp3 was determined by immunohis-tochemistry in three consecutive sections per sample. RESULTS: Compared with healthy controls, there was an increased number of CD25 + and Foxp3 + cells in patients with gastritis (P = 0.004 and P = 0.008), peptic ulcer (P <0.001 and P <0.001), and gastric cancer (P <0.001 and P <0.001). The ratio of CD25 +/CD4 + or Foxp3 +/CD4 + cells was also significantly higher in all disease groups (P <0.001, respectively). The number of CD4 +, CD25 +, and Foxp3 + cells, and the ratio of CD25 +/CD4 + and Foxp3 +/CD4 + cells, were associated with the histological grade of the specimens, including acute inflammation, chronic inflammation, lymphoid follicle number, and Helicobacter pylori infection. The number of CD4 +, CD25 + and Foxp3 + cells, and the ratio of CD25 +/CD4 + and Foxp3 +/CD4 + cells, were negatively associated with intestinal metaplasia among gastritis (P <0.001, P <0.001, P <0.001, P = 0.002 and P = 0.002) and peptic ulcer groups (P = 0.013, P = 0.004, P <0.001, P = 0.040 and P = 0.003). CONCLUSION: Tregs are positively associated with endoscopic findings of gastroduodenal diseases and histological grade but negatively associated with intestinal metaplasia in gastritis and peptic ulcer groups.

原文英語
頁(從 - 到)34-43
頁數10
期刊World Journal of Gastroenterology
18
發行號1
DOIs
出版狀態已發佈 - 一月 7 2012

ASJC Scopus subject areas

  • 消化內科

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