Increased leukocyte Rho-associated coiled-coil containing protein kinase activity predicts the presence and severity of coronary vasospastic angina

Ming Jui Hung, Wen Jin Cherng, Ming Yow Hung, Li Tang Kuo, Chi Wen Cheng, Chao Hung Wang, Ning I. Yang, James K. Liao

研究成果: 雜誌貢獻 › 文章

22 引文 斯高帕斯（Scopus）

摘要

Objective: Although inhibition of Rho-associated coiled-coil containing protein kinase (ROCK) has been shown to prevent coronary vasospastic angina (CVA), direct evidence linking ROCK activity and CVA is lacking. Accordingly, we investigated whether ROCK activity is an independent marker for CVA and is altered after treatment with antispastic medications. Methods and results: We prospectively studied 31 Taiwanese patients who were diagnosed with CVA and 33 control subjects. Subject demographics were recorded, and blood samples were obtained at baseline in all participants and in CVA patients after 3 months of antispastic treatment. Compared with control subjects, leukocyte ROCK activity was greater in CVA patients (136% versus 91%, P

原文英語
頁（從 - 到）521-526
頁數6
期刊Atherosclerosis
卷221
發行號2
DOIs
出版狀態已發佈 - 四月 2012

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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