摘要

Enolase-α (ENO-1) is a key glycolytic enzyme that has been used as a diagnostic marker to identify human lung cancers. To investigate the role of ENO-1 in breast cancer diagnosis and therapy, the mRNA levels of ENO-1 in 244 tumor and normal paired tissue samples and 20 laser capture-microdissected cell clusters were examined by quantitative real-time PCR analysis. Increased ENO-1 mRNA expression was preferentially detected in estrogen receptor-positive (ER+) tumors (tumor/normal ratio >90fold) when compared to ER-negative (tumor/normal ratio >20-fold) tumor tissues. The data presented here demonstrate that those patients whose tumors highly expressed ENO-1 had a poor prognosis with greater tumor size (>2 cm, *P = .017), poor nodal status (N > 3, *P = .018), and a shorter disease-free interval (≤1 year, *P
原文英語
頁(從 - 到)539-553
頁數15
期刊Breast Cancer Research and Treatment
121
發行號3
DOIs
出版狀態已發佈 - 六月 2010

ASJC Scopus subject areas

  • 腫瘤科
  • 癌症研究

指紋

深入研究「Increased expression of enolase α in human breast cancer confers tamoxifen resistance in human breast cancer cells」主題。共同形成了獨特的指紋。

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