Increased expression of carbonic anhydrase IX in oral submucous fibrosis and oral squamous cell carcinoma

Jia Sin Yang, Mu Kuan Chen, Shun Fa Yang, Yu Chao Chang, Shih Chi Su, Hui Ling Chiou, Ming Hsien Chien, Chiao Wen Lin

研究成果: 雜誌貢獻文章

12 引文 (Scopus)

摘要

Background: Cumulative evidence has demonstrated that carbonic anhydrase IX (CAIX) is upregulated in many types of human cancers. We attempted to evaluate plasma levels of CAIX in patients with oral cancer and investigated whether plasma CAIX is correlated with the progression of this disease. Method: In total, 191 patients with oral cancer, 30 patients with oral submucous fibrosis and 100 controls were recruited in this study. The plasma samples were collected and the levels of soluble CAIX in plasma were determined by the enzyme-linked immunosorbent assay (ELISA). Furthermore, the normal buccal mucosa fibroblast was challenged by arecoline, the major areca nut alkaloid, to assess the relationship between the levels of CAIX and areca nut chewing in oral cancer patients. Results: Results showed that patients with oral cancer exhibited significantly higher levels of soluble CAIX compared to controls (p

原文英語
頁(從 - 到)1367-1377
頁數11
期刊Clinical Chemistry and Laboratory Medicine
52
發行號9
DOIs
出版狀態已發佈 - 九月 1 2014

指紋

Oral Submucous Fibrosis
Carbonic Anhydrases
Squamous Cell Carcinoma
Mouth Neoplasms
Areca
Plasmas
Nuts
Arecoline
Mastication
Immunosorbents
Mouth Mucosa
Fibroblasts
Alkaloids
Disease Progression
Carbonic Anhydrase IX
Epithelial Cells
Assays
Enzyme-Linked Immunosorbent Assay
Enzymes

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Medicine(all)

引用此文

Increased expression of carbonic anhydrase IX in oral submucous fibrosis and oral squamous cell carcinoma. / Yang, Jia Sin; Chen, Mu Kuan; Yang, Shun Fa; Chang, Yu Chao; Su, Shih Chi; Chiou, Hui Ling; Chien, Ming Hsien; Lin, Chiao Wen.

於: Clinical Chemistry and Laboratory Medicine, 卷 52, 編號 9, 01.09.2014, p. 1367-1377.

研究成果: 雜誌貢獻文章

Yang, Jia Sin ; Chen, Mu Kuan ; Yang, Shun Fa ; Chang, Yu Chao ; Su, Shih Chi ; Chiou, Hui Ling ; Chien, Ming Hsien ; Lin, Chiao Wen. / Increased expression of carbonic anhydrase IX in oral submucous fibrosis and oral squamous cell carcinoma. 於: Clinical Chemistry and Laboratory Medicine. 2014 ; 卷 52, 編號 9. 頁 1367-1377.
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abstract = "Background: Cumulative evidence has demonstrated that carbonic anhydrase IX (CAIX) is upregulated in many types of human cancers. We attempted to evaluate plasma levels of CAIX in patients with oral cancer and investigated whether plasma CAIX is correlated with the progression of this disease. Method: In total, 191 patients with oral cancer, 30 patients with oral submucous fibrosis and 100 controls were recruited in this study. The plasma samples were collected and the levels of soluble CAIX in plasma were determined by the enzyme-linked immunosorbent assay (ELISA). Furthermore, the normal buccal mucosa fibroblast was challenged by arecoline, the major areca nut alkaloid, to assess the relationship between the levels of CAIX and areca nut chewing in oral cancer patients. Results: Results showed that patients with oral cancer exhibited significantly higher levels of soluble CAIX compared to controls (p",
keywords = "Carbonic anhydrase IX (CAIX), Chewed areca nuts, Oral cancer, Oral submucous fibrosis",
author = "Yang, {Jia Sin} and Chen, {Mu Kuan} and Yang, {Shun Fa} and Chang, {Yu Chao} and Su, {Shih Chi} and Chiou, {Hui Ling} and Chien, {Ming Hsien} and Lin, {Chiao Wen}",
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T1 - Increased expression of carbonic anhydrase IX in oral submucous fibrosis and oral squamous cell carcinoma

AU - Yang, Jia Sin

AU - Chen, Mu Kuan

AU - Yang, Shun Fa

AU - Chang, Yu Chao

AU - Su, Shih Chi

AU - Chiou, Hui Ling

AU - Chien, Ming Hsien

AU - Lin, Chiao Wen

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Background: Cumulative evidence has demonstrated that carbonic anhydrase IX (CAIX) is upregulated in many types of human cancers. We attempted to evaluate plasma levels of CAIX in patients with oral cancer and investigated whether plasma CAIX is correlated with the progression of this disease. Method: In total, 191 patients with oral cancer, 30 patients with oral submucous fibrosis and 100 controls were recruited in this study. The plasma samples were collected and the levels of soluble CAIX in plasma were determined by the enzyme-linked immunosorbent assay (ELISA). Furthermore, the normal buccal mucosa fibroblast was challenged by arecoline, the major areca nut alkaloid, to assess the relationship between the levels of CAIX and areca nut chewing in oral cancer patients. Results: Results showed that patients with oral cancer exhibited significantly higher levels of soluble CAIX compared to controls (p

AB - Background: Cumulative evidence has demonstrated that carbonic anhydrase IX (CAIX) is upregulated in many types of human cancers. We attempted to evaluate plasma levels of CAIX in patients with oral cancer and investigated whether plasma CAIX is correlated with the progression of this disease. Method: In total, 191 patients with oral cancer, 30 patients with oral submucous fibrosis and 100 controls were recruited in this study. The plasma samples were collected and the levels of soluble CAIX in plasma were determined by the enzyme-linked immunosorbent assay (ELISA). Furthermore, the normal buccal mucosa fibroblast was challenged by arecoline, the major areca nut alkaloid, to assess the relationship between the levels of CAIX and areca nut chewing in oral cancer patients. Results: Results showed that patients with oral cancer exhibited significantly higher levels of soluble CAIX compared to controls (p

KW - Carbonic anhydrase IX (CAIX)

KW - Chewed areca nuts

KW - Oral cancer

KW - Oral submucous fibrosis

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