Increased admission serum estradiol level is correlated with high mortality in patients with severe acute pancreatitis

Chih Wei Lu, Liang Chih Liu, Ya Ching Hsieh, Li Heng Yang, Ray Jade Chen, Chi Hsun Hsieh

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8 引文 斯高帕斯(Scopus)

摘要

Background Sexual dimorphism in critical diseases has been documented. Severe acute pancreatitis is a disease with high mortality. We hypothesized that admission sex hormone levels may be used as an early predictor of outcome in these patients. Methods A prospective cohort of patients with severe acute pancreatitis admitted to the intensive care unit for at least 48 h were enrolled (n = 62). Serum levels of estradiol, progesterone, and testosterone were determined on admission. The association of sex hormone levels and various disease severity scoring systems with patient outcome was analyzed. Results There was no difference in overall mortality between the sexes. However, estradiol was significantly elevated in nonsurvivors (39 vs. 206 pg/mL, p

原文英語
頁(從 - 到)374-381
頁數8
期刊Journal of Gastroenterology
48
發行號3
DOIs
出版狀態已發佈 - 三月 2013

ASJC Scopus subject areas

  • Gastroenterology

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