Increase of plasma neuropeptide Y-like immunoreactivity following chronic hypoxia in the rat

Juei Tang Cheng, Chau Fong Chen, Andrew Y.C. Shum, Jia Yi Wang, Hsing I. Chen

研究成果: 雜誌貢獻文章同行評審

18 引文 斯高帕斯(Scopus)

摘要

In an attempt to understand the changes of circulating neuropeptide Y (NPY) during hypoxia, the plasma level of NPY was investigated by radioimmunoassay. Exposure of rats to hypobaric hypoxia at an altitude of 18,000 ft for 4 weeks causes an increase of pulmonary pressure and an elevation of plasma NPY-like immunoreactivity (NPY-LI). However, the systemic blood pressure was not elevated by this chronic hypoxia. Also, plasma noradrenaline (NA) estimated by chromatographic analysis (HPLC-ECD) was not markedly raised. Failure of bretylium and guanethidine, sympathetic neuron blockers, in reducing the plasma NPY-LI level of these rats ruled out the participation of adrenergic nervous terminals. Adrenal medulla seems responsible for this elevation of plasma NPY-LI because this magnitude disappeared in adrenalectomized rats. These data suggest that chronic hypoxia induced an elevation of circulating NPY from the adrenal gland of rats.
原文英語
頁(從 - 到)211-214
頁數4
期刊Neuroscience Letters
140
發行號2
DOIs
出版狀態已發佈 - 六月 22 1992
對外發佈

ASJC Scopus subject areas

  • 神經科學 (全部)

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