Increase of cardiac M2-muscarinic receptor gene expression in type-1 but not in type-2 diabetic rats

Liang Ming Lee, Cheng Kuei Chang, Kai Chun Cheng, Dai Huang Kou, I. Min Liu, Juei Tang Cheng

研究成果: 雜誌貢獻文章

5 引文 (Scopus)

摘要

Changes of cardiac M2-muscarinic receptor (M2-mAChR) gene expression was investigated in type-1 like diabetic rats induced by intravenous injection of streptozotocin (STZ) and type-2 like diabetic rats induced by fed with fructose-rich chow. Systolic blood pressure (SBP) in STZ-diabetic rats was significantly lower than that in age-matched non-diabetic rats, while the SBP in type-2 like diabetic rats was higher than in non-diabetic rats. Also, the mRNA or protein level of cardiac M2-mAChR in STZ-diabetic rats was markedly higher than non-diabetic rats, but it was not observed in type-2 like diabetic rats as compared to age-matched non-diabetic rats. Arecaidine propargyl ester (APE), the agonist of M2-mAChR, produced a marked reduction of heart rate in STZ-diabetic rats but made less influence on heart rate in fructose-fed rats or non-diabetic rats. The results suggest that cardiac M2-mAChR gene expression is raised in type-1 like diabetic rats but not in type-2 like diabetic rats, this difference mainly due to hyperglycemia, for the production of hypotension in diabetic disorders.
原文英語
頁(從 - 到)201-204
頁數4
期刊Neuroscience Letters
441
發行號2
DOIs
出版狀態已發佈 - 八月 22 2008

指紋

Muscarinic M2 Receptors
Gene Expression
Streptozocin
Blood Pressure
Fructose
Heart Rate

ASJC Scopus subject areas

  • Neuroscience(all)

引用此文

Increase of cardiac M2-muscarinic receptor gene expression in type-1 but not in type-2 diabetic rats. / Lee, Liang Ming; Chang, Cheng Kuei; Cheng, Kai Chun; Kou, Dai Huang; Liu, I. Min; Cheng, Juei Tang.

於: Neuroscience Letters, 卷 441, 編號 2, 22.08.2008, p. 201-204.

研究成果: 雜誌貢獻文章

Lee, Liang Ming ; Chang, Cheng Kuei ; Cheng, Kai Chun ; Kou, Dai Huang ; Liu, I. Min ; Cheng, Juei Tang. / Increase of cardiac M2-muscarinic receptor gene expression in type-1 but not in type-2 diabetic rats. 於: Neuroscience Letters. 2008 ; 卷 441, 編號 2. 頁 201-204.
@article{b8138dd2defe4d4192c9ae253b4370a9,
title = "Increase of cardiac M2-muscarinic receptor gene expression in type-1 but not in type-2 diabetic rats",
abstract = "Changes of cardiac M2-muscarinic receptor (M2-mAChR) gene expression was investigated in type-1 like diabetic rats induced by intravenous injection of streptozotocin (STZ) and type-2 like diabetic rats induced by fed with fructose-rich chow. Systolic blood pressure (SBP) in STZ-diabetic rats was significantly lower than that in age-matched non-diabetic rats, while the SBP in type-2 like diabetic rats was higher than in non-diabetic rats. Also, the mRNA or protein level of cardiac M2-mAChR in STZ-diabetic rats was markedly higher than non-diabetic rats, but it was not observed in type-2 like diabetic rats as compared to age-matched non-diabetic rats. Arecaidine propargyl ester (APE), the agonist of M2-mAChR, produced a marked reduction of heart rate in STZ-diabetic rats but made less influence on heart rate in fructose-fed rats or non-diabetic rats. The results suggest that cardiac M2-mAChR gene expression is raised in type-1 like diabetic rats but not in type-2 like diabetic rats, this difference mainly due to hyperglycemia, for the production of hypotension in diabetic disorders.",
keywords = "Cardiac M-muscarinic receptor, Gene expression, Hyperglycemia, Insulin resistance",
author = "Lee, {Liang Ming} and Chang, {Cheng Kuei} and Cheng, {Kai Chun} and Kou, {Dai Huang} and Liu, {I. Min} and Cheng, {Juei Tang}",
year = "2008",
month = "8",
day = "22",
doi = "10.1016/j.neulet.2008.06.003",
language = "English",
volume = "441",
pages = "201--204",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Increase of cardiac M2-muscarinic receptor gene expression in type-1 but not in type-2 diabetic rats

AU - Lee, Liang Ming

AU - Chang, Cheng Kuei

AU - Cheng, Kai Chun

AU - Kou, Dai Huang

AU - Liu, I. Min

AU - Cheng, Juei Tang

PY - 2008/8/22

Y1 - 2008/8/22

N2 - Changes of cardiac M2-muscarinic receptor (M2-mAChR) gene expression was investigated in type-1 like diabetic rats induced by intravenous injection of streptozotocin (STZ) and type-2 like diabetic rats induced by fed with fructose-rich chow. Systolic blood pressure (SBP) in STZ-diabetic rats was significantly lower than that in age-matched non-diabetic rats, while the SBP in type-2 like diabetic rats was higher than in non-diabetic rats. Also, the mRNA or protein level of cardiac M2-mAChR in STZ-diabetic rats was markedly higher than non-diabetic rats, but it was not observed in type-2 like diabetic rats as compared to age-matched non-diabetic rats. Arecaidine propargyl ester (APE), the agonist of M2-mAChR, produced a marked reduction of heart rate in STZ-diabetic rats but made less influence on heart rate in fructose-fed rats or non-diabetic rats. The results suggest that cardiac M2-mAChR gene expression is raised in type-1 like diabetic rats but not in type-2 like diabetic rats, this difference mainly due to hyperglycemia, for the production of hypotension in diabetic disorders.

AB - Changes of cardiac M2-muscarinic receptor (M2-mAChR) gene expression was investigated in type-1 like diabetic rats induced by intravenous injection of streptozotocin (STZ) and type-2 like diabetic rats induced by fed with fructose-rich chow. Systolic blood pressure (SBP) in STZ-diabetic rats was significantly lower than that in age-matched non-diabetic rats, while the SBP in type-2 like diabetic rats was higher than in non-diabetic rats. Also, the mRNA or protein level of cardiac M2-mAChR in STZ-diabetic rats was markedly higher than non-diabetic rats, but it was not observed in type-2 like diabetic rats as compared to age-matched non-diabetic rats. Arecaidine propargyl ester (APE), the agonist of M2-mAChR, produced a marked reduction of heart rate in STZ-diabetic rats but made less influence on heart rate in fructose-fed rats or non-diabetic rats. The results suggest that cardiac M2-mAChR gene expression is raised in type-1 like diabetic rats but not in type-2 like diabetic rats, this difference mainly due to hyperglycemia, for the production of hypotension in diabetic disorders.

KW - Cardiac M-muscarinic receptor

KW - Gene expression

KW - Hyperglycemia

KW - Insulin resistance

UR - http://www.scopus.com/inward/record.url?scp=46949108465&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=46949108465&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2008.06.003

DO - 10.1016/j.neulet.2008.06.003

M3 - Article

C2 - 18603373

AN - SCOPUS:46949108465

VL - 441

SP - 201

EP - 204

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -