Increase in the production of interleukin-10 early after implantation is related to the success of pregnancy

Ming Yih Wu, Hsin Fu Chen, Shee Uan Chen, Kuang Han Chao, Yu Shih Yang, Hong Nerng Ho

研究成果: 雜誌貢獻文章同行評審

43 引文 斯高帕斯(Scopus)

摘要

Problem: To study the correlation of interleukin (IL)-10, IL-11 leukemia inhibitory factor (LIF), placental growth factor (P1GF), and transforming growth factor (TGF)-β and outcome of human pregnancy. Method of study: We prospectively measured the serum levels of these cytokines in patients undergoing in vitro fertilization (IVF) programs. A total of 60 women (non-pregnant, n = 27; early abortions, n = 12; normal pregnancies, n = 21) were enrolled. Results: There was no difference in the cytokines studied on D0 and D14 among the three groups of women. The increase in P1GF from D0 to D14 after human chorionic gonadotropin (hCG) injection was greater in pregnant women than in non-pregnant women; however, the difference did not reach significance (P = 0.068). The increase in IL-10 production from D14 and D21 was significant in women with successful pregnancies compared to women in the abortion group. Conclusions: This increase in IL-10 may be important in sustaining a normal pregnancy early after implantation.
原文英語
頁(從 - 到)386-392
頁數7
期刊American Journal of Reproductive Immunology
46
發行號6
DOIs
出版狀態已發佈 - 一月 1 2001
對外發佈

ASJC Scopus subject areas

  • 免疫學和過敏
  • 免疫學
  • 生殖醫學
  • 婦產科

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