Increase in the expression of killer cell inhibitory receptors on peritoneal natural killer cells in women with endometriosis

Ming Yih Wu, Jehn Hsiahn Yang, Kuang Han Chao, Jiann Loung Hwang, Yu Shih Yang, Hong Nerng Ho

研究成果: 雜誌貢獻文章同行評審

63 引文 斯高帕斯(Scopus)

摘要

Objective: Malfunction of peritoneal natural killer cells (NK) may result in endometriosis. The present study was designed to determine whether the decrease in NK cytotoxicity occurs at early and advanced stages of endometriosis and is due to the increase in the NK inhibition receptors. Design: A case control study. Setting: A tertiary-care infertility center. Patient(s): A total of 44 women (controls, n = 11; women with early-stage endometriosis, n = 11; and women with advanced-stage endometriosis, n = 22) were included in this study. Intervention(s): Laparoscopic examination. Main Outcome Measure(s): NK cytotoxicity was determined by assay of 51Cr release against K562 cells, and the expression of killer cell inhibitory receptors (KIR, including NKB1, GL183, and EB6) in NK cells was examined by flow cytometry. Result(s): Women with endometriosis showed a decrease in peritoneal NK cytotoxicities against K562 at early and advanced stages of endometriosis. The expression of KIR (NKB1 and EB6) was significantly elevated in the peritoneal NK cells of women with advanced-stage endometriosis compared with controls. KIR (NKB1) was also significantly increased in peritoneal NK cells of women with advanced-stage endometriosis, compared with those of women with early-stage endometriosis. Conclusion(s): The results of this study suggest that the decrease in peritoneal NK cytotoxicities against K562 is observed and that this disease may be partially due to the increased expression of KIR on these NK cells. Copyright (C) 2000 American Society for Reproductive Medicine.
原文英語
頁(從 - 到)1187-1191
頁數5
期刊Fertility and Sterility
74
發行號6
DOIs
出版狀態已發佈 - 十二月 28 2000
對外發佈

ASJC Scopus subject areas

  • 生殖醫學
  • 婦產科

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