Increase in 12-lipoxygenase activity in platelets of spontaneously hypertensive rats

Wen Chang Chang, Gin Wen Su

研究成果: 雜誌貢獻文章

8 引文 斯高帕斯(Scopus)

摘要

12-Lipoxygenase activity in platelets of spontaneously hypertensive rats was investigated. Enzyme activity was measured in the absence and the presence of reduced glutathione. In both assay conditions, 12-lipoxygenase activity in platelets of spontaneously hypertensive rats was significantly higher than that in platelets of normotensive rats. Since 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE), a 12-lipoxygenase product of arachidonic acid in platelets, has been reported to be a potent chemoattractant for aortic smooth muscle cells, increase in biosynthesis of 12-HETE in platelets of spontaneously hypertensive rats might contribute to the explanation of pathogenesis of vascular disorder commonly found in hypertension patients.

原文英語
頁(從 - 到)642-648
頁數7
期刊Biochemical and Biophysical Research Communications
127
發行號2
DOIs
出版狀態已發佈 - 三月 15 1985
對外發佈Yes

    指紋

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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