Inclusion of biological factors in parallel-architecture normal-tissue complication probability model for radiation-induced liver disease

Jason Chia Hsien Cheng, Hua Shan Liu, Jian Kuen Wu, Hsiao Wen Chung, Gwo Jen Jan

研究成果: 雜誌貢獻文章

33 引文 (Scopus)

摘要

Purpose: To include biologic factors in parallel-architecture normal-tissue complication probability (NTCP) model for radiation-induced liver disease (RILD) after three-dimensional conformal radiotherapy (3D-CRT) for gastric or hepatic cancer. Methods and Materials: A total of 151 patients (89 with hepatocellular carcinoma and 62 with gastric cancer) who received 3D-CRT to the liver were included (isocenter dose range 33.0 to 66.0 Gy; mean 48.0 Gy). RILD was defined as grade 3 or higher liver toxicity according to Common Toxicity Criteria Version 2.0 of the National Cancer Institute within 4 months after 3D-CRT. Possible correlations of patient-related or dosimetric factors with RILD were tested. Maximum-likelihood analysis estimated NTCP model parameters for group and subgroups. Goodness-of-fit analysis estimated deviance of NTCP model parameters between subgroups. Results: RILD developed in 25 patients. Hepatitis B virus carrier status (p <0.001) was the only significant independent factor. The 4 parallel NTCP model parameters, mean functional reserve (V 50), width of functional reserve distribution (σ), dose damage to 50% of liver subunits (D50), and slope parameter for subunit dose-response (k), were respectively, 0.54, 0.14, 50 Gy, 0.18 (group); 0.53, 0.07, 50 Gy, 4.6 × 10-7 (carriers); 0.59, 0.12, 25 Gy, 59.8 (noncarriers). In carrier-state subgroups, goodness-of-fit deviance with 1 subgroup's parameter set would have been worse in the other group. Across subgroups, patients with RILD all had liver fraction damage (f) greater than 0.4 compared with wider distribution for the whole group. Conclusions: RILD is described with a parallel-architecture NTCP model for HBV carriers and noncarriers with a threshold effect greater than 0.4. The main difference is in slope parameter for subunit dose-response.

原文英語
頁(從 - 到)1150-1156
頁數7
期刊International Journal of Radiation Oncology Biology Physics
62
發行號4
DOIs
出版狀態已發佈 - 七月 15 2005
對外發佈Yes

指紋

Biological Factors
liver
Liver Diseases
inclusions
Radiation
radiation
subgroups
Liver
cancer
Stomach Neoplasms
goodness of fit
dosage
Conformal Radiotherapy
Carrier State
National Cancer Institute (U.S.)
toxicity
Liver Neoplasms
Hepatitis B virus
Hepatocellular Carcinoma
slopes

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

引用此文

Inclusion of biological factors in parallel-architecture normal-tissue complication probability model for radiation-induced liver disease. / Cheng, Jason Chia Hsien; Liu, Hua Shan; Wu, Jian Kuen; Chung, Hsiao Wen; Jan, Gwo Jen.

於: International Journal of Radiation Oncology Biology Physics, 卷 62, 編號 4, 15.07.2005, p. 1150-1156.

研究成果: 雜誌貢獻文章

@article{8ce2e18bb3c44958b01aeed7c4c4b55a,
title = "Inclusion of biological factors in parallel-architecture normal-tissue complication probability model for radiation-induced liver disease",
abstract = "Purpose: To include biologic factors in parallel-architecture normal-tissue complication probability (NTCP) model for radiation-induced liver disease (RILD) after three-dimensional conformal radiotherapy (3D-CRT) for gastric or hepatic cancer. Methods and Materials: A total of 151 patients (89 with hepatocellular carcinoma and 62 with gastric cancer) who received 3D-CRT to the liver were included (isocenter dose range 33.0 to 66.0 Gy; mean 48.0 Gy). RILD was defined as grade 3 or higher liver toxicity according to Common Toxicity Criteria Version 2.0 of the National Cancer Institute within 4 months after 3D-CRT. Possible correlations of patient-related or dosimetric factors with RILD were tested. Maximum-likelihood analysis estimated NTCP model parameters for group and subgroups. Goodness-of-fit analysis estimated deviance of NTCP model parameters between subgroups. Results: RILD developed in 25 patients. Hepatitis B virus carrier status (p <0.001) was the only significant independent factor. The 4 parallel NTCP model parameters, mean functional reserve (V 50), width of functional reserve distribution (σ), dose damage to 50{\%} of liver subunits (D50), and slope parameter for subunit dose-response (k), were respectively, 0.54, 0.14, 50 Gy, 0.18 (group); 0.53, 0.07, 50 Gy, 4.6 × 10-7 (carriers); 0.59, 0.12, 25 Gy, 59.8 (noncarriers). In carrier-state subgroups, goodness-of-fit deviance with 1 subgroup's parameter set would have been worse in the other group. Across subgroups, patients with RILD all had liver fraction damage (f) greater than 0.4 compared with wider distribution for the whole group. Conclusions: RILD is described with a parallel-architecture NTCP model for HBV carriers and noncarriers with a threshold effect greater than 0.4. The main difference is in slope parameter for subunit dose-response.",
keywords = "Hepatitis B virus, Normal-tissue complication probability, Parameterization, Radiation-induced liver disease",
author = "Cheng, {Jason Chia Hsien} and Liu, {Hua Shan} and Wu, {Jian Kuen} and Chung, {Hsiao Wen} and Jan, {Gwo Jen}",
year = "2005",
month = "7",
day = "15",
doi = "10.1016/j.ijrobp.2004.12.031",
language = "English",
volume = "62",
pages = "1150--1156",
journal = "International Journal of Radiation Oncology Biology Physics",
issn = "0360-3016",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Inclusion of biological factors in parallel-architecture normal-tissue complication probability model for radiation-induced liver disease

AU - Cheng, Jason Chia Hsien

AU - Liu, Hua Shan

AU - Wu, Jian Kuen

AU - Chung, Hsiao Wen

AU - Jan, Gwo Jen

PY - 2005/7/15

Y1 - 2005/7/15

N2 - Purpose: To include biologic factors in parallel-architecture normal-tissue complication probability (NTCP) model for radiation-induced liver disease (RILD) after three-dimensional conformal radiotherapy (3D-CRT) for gastric or hepatic cancer. Methods and Materials: A total of 151 patients (89 with hepatocellular carcinoma and 62 with gastric cancer) who received 3D-CRT to the liver were included (isocenter dose range 33.0 to 66.0 Gy; mean 48.0 Gy). RILD was defined as grade 3 or higher liver toxicity according to Common Toxicity Criteria Version 2.0 of the National Cancer Institute within 4 months after 3D-CRT. Possible correlations of patient-related or dosimetric factors with RILD were tested. Maximum-likelihood analysis estimated NTCP model parameters for group and subgroups. Goodness-of-fit analysis estimated deviance of NTCP model parameters between subgroups. Results: RILD developed in 25 patients. Hepatitis B virus carrier status (p <0.001) was the only significant independent factor. The 4 parallel NTCP model parameters, mean functional reserve (V 50), width of functional reserve distribution (σ), dose damage to 50% of liver subunits (D50), and slope parameter for subunit dose-response (k), were respectively, 0.54, 0.14, 50 Gy, 0.18 (group); 0.53, 0.07, 50 Gy, 4.6 × 10-7 (carriers); 0.59, 0.12, 25 Gy, 59.8 (noncarriers). In carrier-state subgroups, goodness-of-fit deviance with 1 subgroup's parameter set would have been worse in the other group. Across subgroups, patients with RILD all had liver fraction damage (f) greater than 0.4 compared with wider distribution for the whole group. Conclusions: RILD is described with a parallel-architecture NTCP model for HBV carriers and noncarriers with a threshold effect greater than 0.4. The main difference is in slope parameter for subunit dose-response.

AB - Purpose: To include biologic factors in parallel-architecture normal-tissue complication probability (NTCP) model for radiation-induced liver disease (RILD) after three-dimensional conformal radiotherapy (3D-CRT) for gastric or hepatic cancer. Methods and Materials: A total of 151 patients (89 with hepatocellular carcinoma and 62 with gastric cancer) who received 3D-CRT to the liver were included (isocenter dose range 33.0 to 66.0 Gy; mean 48.0 Gy). RILD was defined as grade 3 or higher liver toxicity according to Common Toxicity Criteria Version 2.0 of the National Cancer Institute within 4 months after 3D-CRT. Possible correlations of patient-related or dosimetric factors with RILD were tested. Maximum-likelihood analysis estimated NTCP model parameters for group and subgroups. Goodness-of-fit analysis estimated deviance of NTCP model parameters between subgroups. Results: RILD developed in 25 patients. Hepatitis B virus carrier status (p <0.001) was the only significant independent factor. The 4 parallel NTCP model parameters, mean functional reserve (V 50), width of functional reserve distribution (σ), dose damage to 50% of liver subunits (D50), and slope parameter for subunit dose-response (k), were respectively, 0.54, 0.14, 50 Gy, 0.18 (group); 0.53, 0.07, 50 Gy, 4.6 × 10-7 (carriers); 0.59, 0.12, 25 Gy, 59.8 (noncarriers). In carrier-state subgroups, goodness-of-fit deviance with 1 subgroup's parameter set would have been worse in the other group. Across subgroups, patients with RILD all had liver fraction damage (f) greater than 0.4 compared with wider distribution for the whole group. Conclusions: RILD is described with a parallel-architecture NTCP model for HBV carriers and noncarriers with a threshold effect greater than 0.4. The main difference is in slope parameter for subunit dose-response.

KW - Hepatitis B virus

KW - Normal-tissue complication probability

KW - Parameterization

KW - Radiation-induced liver disease

UR - http://www.scopus.com/inward/record.url?scp=21244473927&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21244473927&partnerID=8YFLogxK

U2 - 10.1016/j.ijrobp.2004.12.031

DO - 10.1016/j.ijrobp.2004.12.031

M3 - Article

C2 - 15990021

AN - SCOPUS:21244473927

VL - 62

SP - 1150

EP - 1156

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

SN - 0360-3016

IS - 4

ER -