Incidence rates of enterovirus 71 infections in young children during a nationwide epidemic in taiwan, 2008-09

Min Shi Lee, Pai Shan Chiang, Shu Ting Luo, Mei Liang Huang, Guan Yuan Liou, Kuo Chien Tsao, Tzou Yien Lin

研究成果: 雜誌貢獻文章同行評審

36 引文 斯高帕斯(Scopus)

摘要

Objective: Enterovirus 71 (EV71) is causing life-threatening outbreaks in tropical Asia. In Taiwan and other tropical Asian countries, although nationwide EV71 epidemics occur cyclically, age-specific incidence rates of EV71 infections that are critical to estimate disease burden and design vaccine trials are not clear. A nationwide EV71 epidemic occurred in 2008-09 in Taiwan, which provided a unique opportunity to estimate age-specific incidence rates of EV71 infections. Study Design: We prospectively recruited 749 healthy neonates and conducted follow-ups from June 2006 to December 2009. Sera were obtained from participants at 0, 6, 12, 24, and 36 months of age for measuring EV71 neutralizing antibody titers. If the participants developed suspected enterovirus illnesses, throat swabs were collected for virus isolation. Results: We detected 28 EV71 infections including 20 symptomatic and 8 asymptomatic infections. Age-specific incidence rates of EV71 infection increased from 1.71 per 100 person-years at 0-6 months of age to 4.09, 5.74, and 4.97 per 100 person-years at 7-12, 13-24, and 25-36 months of age, respectively. Cumulative incidence rate was 15.15 per 100 persons by 36 months of age, respectively. Conclusions: Risk of EV71 infections in Taiwan increased after 6 months of age during EV71 epidemics. The cumulative incidence rate was 15% by 36 months of age, and 29% of EV71 infections were asymptomatic in young children.
原文英語
文章編號e1476
期刊PLoS Neglected Tropical Diseases
6
發行號2
DOIs
出版狀態已發佈 - 二月 2012
對外發佈

ASJC Scopus subject areas

  • 藥理學、毒理學和藥劑學 (全部)
  • 公共衛生、環境和職業健康
  • 傳染性疾病

指紋

深入研究「Incidence rates of enterovirus 71 infections in young children during a nationwide epidemic in taiwan, 2008-09」主題。共同形成了獨特的指紋。

引用此