Incidence of internal cancers and ingested inorganic arsenic: A seven-year follow-up study in Taiwan

Hung Yi Chiou, Yu Mei Hsueh, Kuen Fu Liaw, Shan Far Horng, Ming Hsi Chiang, Yeong Shiau Pu, Johnny Shinn Nan Lin, Chun Hsiung Huang, Chien Jen Chen

研究成果: 雜誌貢獻文章

394 引文 斯高帕斯(Scopus)

摘要

In order to elucidate the dose-response relationship between ingested inorganic arsenic and internal cancers, a total of 263 patients with black-foot disease and 2293 healthy residents in the endemic area of arseniasis were recruited and followed up for 7 years. The information on consumption of high-arsenic artesian well water, sociodemographic characteristics, life-style and dietary habits, and personal and family history of cancers was obtained through standardized interviews. The occurrence of internal cancers among study subjects was determined through annual health examinations, home visit personal interviews, household registration data checks, and national death certification and cancer registry profile linkages. A dose-response relationship was observed between the long-term arsenic exposure from drinking artesian well water and the incidence of lung cancer, bladder cancer, and cancers of all sites combined after adjustment for age, sex, and cigarette smoking through Cox's proportional hazards regression analysis. Blackfoot disease patients had a significantly increased cancer incidence after adjustment for cumulative arsenic exposure.
原文英語
頁(從 - 到)1296-1300
頁數5
期刊Cancer Research
55
發行號6
出版狀態已發佈 - 三月 15 1995

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Chiou, H. Y., Hsueh, Y. M., Liaw, K. F., Horng, S. F., Chiang, M. H., Pu, Y. S., Lin, J. S. N., Huang, C. H., & Chen, C. J. (1995). Incidence of internal cancers and ingested inorganic arsenic: A seven-year follow-up study in Taiwan. Cancer Research, 55(6), 1296-1300.