Incidence of autoimmune diseases in a nationwide HIV/AIDS patient cohort in Taiwan, 2000-2012

Yung Feng Yen, Pei Hung Chuang, I. An Jen, Marcelo Chen, Yu Ching Lan, Yen Ling Liu, Yun Lee, Yen Hsu Chen, Yi Ming Arthur Chen

研究成果: 雜誌貢獻文章

19 引文 (Scopus)

摘要

Objectives It is not known if the incidences of autoimmune diseases are higher in individuals living with HIV infection or AIDS. Our study investigated the incidences of autoimmune diseases among people living with HIV/AIDS (PLWHA) in Taiwan during 2000-2012. Methods The Taiwan National Health Insurance Research Database was used to identify PLWHA. The incidence densities of systemic and organ-specific autoimmune diseases were calculated, and age-Adjusted, sex-Adjusted and period-Adjusted standardised incidence rates (SIRs) were obtained by using two million people from the general population as controls. To examine the effects of highly active antiretroviral therapy (HAART) on the incidence of autoimmune diseases, the incidence densities and SIRs of autoimmune diseases were calculated after stratifying PLWHA by HAART status. Results Of the 20â €..444 PLWHA identified, the overall mean (SD) age was 30.1 (11.0) years; 67.2% of the subjects received HAART. As compared with the general population, SIRs were higher for incident Sjögren syndrome (SIR=1.64; 95% CI 1.24 to 2.13), psoriasis (SIR=2.05; 95% CI 1.67 to 2.48), systemic lupus erythematosus (SLE) (SIR=2.59; 95% CI 1.53 to 4.09), autoimmune haemolytic anaemia (SIR=35.06; 95% CI 23.1 to 51.02) and uveitis (SIR=2.50; 95% CI 2.05 to 3.02), but were lower for incident ankylosing spondyloarthritis (SIR=0.70; 95% CI 0.48 to 0.99). When the effect of HAART on incident autoimmune diseases was considered, PLWHA who received HAART had higher SIRs for psoriasis, autoimmune haemolytic anaemia and uveitis, but had lower risks of rheumatoid arthritis (RA) and ankylosing spondyloarthritis. In contrast, PLWHA who did not receive HAART had higher SIRs for Sjögren syndrome, psoriasis, RA, SLE, scleroderma, polymyositis, autoimmune haemolytic anaemia and Hashimoto's thyroiditis. Conclusions PLWHA had higher risks of incident Sjögren syndrome, psoriasis, SLE, autoimmune haemolytic anaemia and uveitis.
原文英語
頁(從 - 到)661-665
頁數5
期刊Annals of the Rheumatic Diseases
76
發行號4
DOIs
出版狀態已發佈 - 四月 1 2017
對外發佈Yes

指紋

Taiwan
Autoimmune Diseases
Acquired Immunodeficiency Syndrome
HIV
Incidence
Highly Active Antiretroviral Therapy
Autoimmune Hemolytic Anemia
Psoriasis
Health insurance
Uveitis
Systemic Lupus Erythematosus
Ankylosing Spondylitis
Rheumatoid Arthritis
Polymyositis
Hashimoto Disease
Population Control
National Health Programs
HIV Infections
Cohort Studies

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

引用此文

Incidence of autoimmune diseases in a nationwide HIV/AIDS patient cohort in Taiwan, 2000-2012. / Yen, Yung Feng; Chuang, Pei Hung; Jen, I. An; Chen, Marcelo; Lan, Yu Ching; Liu, Yen Ling; Lee, Yun; Chen, Yen Hsu; Chen, Yi Ming Arthur.

於: Annals of the Rheumatic Diseases, 卷 76, 編號 4, 01.04.2017, p. 661-665.

研究成果: 雜誌貢獻文章

Yen, Yung Feng ; Chuang, Pei Hung ; Jen, I. An ; Chen, Marcelo ; Lan, Yu Ching ; Liu, Yen Ling ; Lee, Yun ; Chen, Yen Hsu ; Chen, Yi Ming Arthur. / Incidence of autoimmune diseases in a nationwide HIV/AIDS patient cohort in Taiwan, 2000-2012. 於: Annals of the Rheumatic Diseases. 2017 ; 卷 76, 編號 4. 頁 661-665.
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title = "Incidence of autoimmune diseases in a nationwide HIV/AIDS patient cohort in Taiwan, 2000-2012",
abstract = "Objectives It is not known if the incidences of autoimmune diseases are higher in individuals living with HIV infection or AIDS. Our study investigated the incidences of autoimmune diseases among people living with HIV/AIDS (PLWHA) in Taiwan during 2000-2012. Methods The Taiwan National Health Insurance Research Database was used to identify PLWHA. The incidence densities of systemic and organ-specific autoimmune diseases were calculated, and age-Adjusted, sex-Adjusted and period-Adjusted standardised incidence rates (SIRs) were obtained by using two million people from the general population as controls. To examine the effects of highly active antiretroviral therapy (HAART) on the incidence of autoimmune diseases, the incidence densities and SIRs of autoimmune diseases were calculated after stratifying PLWHA by HAART status. Results Of the 20{\^a} €..444 PLWHA identified, the overall mean (SD) age was 30.1 (11.0) years; 67.2{\%} of the subjects received HAART. As compared with the general population, SIRs were higher for incident Sj{\"o}gren syndrome (SIR=1.64; 95{\%} CI 1.24 to 2.13), psoriasis (SIR=2.05; 95{\%} CI 1.67 to 2.48), systemic lupus erythematosus (SLE) (SIR=2.59; 95{\%} CI 1.53 to 4.09), autoimmune haemolytic anaemia (SIR=35.06; 95{\%} CI 23.1 to 51.02) and uveitis (SIR=2.50; 95{\%} CI 2.05 to 3.02), but were lower for incident ankylosing spondyloarthritis (SIR=0.70; 95{\%} CI 0.48 to 0.99). When the effect of HAART on incident autoimmune diseases was considered, PLWHA who received HAART had higher SIRs for psoriasis, autoimmune haemolytic anaemia and uveitis, but had lower risks of rheumatoid arthritis (RA) and ankylosing spondyloarthritis. In contrast, PLWHA who did not receive HAART had higher SIRs for Sj{\"o}gren syndrome, psoriasis, RA, SLE, scleroderma, polymyositis, autoimmune haemolytic anaemia and Hashimoto's thyroiditis. Conclusions PLWHA had higher risks of incident Sj{\"o}gren syndrome, psoriasis, SLE, autoimmune haemolytic anaemia and uveitis.",
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author = "Yen, {Yung Feng} and Chuang, {Pei Hung} and Jen, {I. An} and Marcelo Chen and Lan, {Yu Ching} and Liu, {Yen Ling} and Yun Lee and Chen, {Yen Hsu} and Chen, {Yi Ming Arthur}",
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T1 - Incidence of autoimmune diseases in a nationwide HIV/AIDS patient cohort in Taiwan, 2000-2012

AU - Yen, Yung Feng

AU - Chuang, Pei Hung

AU - Jen, I. An

AU - Chen, Marcelo

AU - Lan, Yu Ching

AU - Liu, Yen Ling

AU - Lee, Yun

AU - Chen, Yen Hsu

AU - Chen, Yi Ming Arthur

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Objectives It is not known if the incidences of autoimmune diseases are higher in individuals living with HIV infection or AIDS. Our study investigated the incidences of autoimmune diseases among people living with HIV/AIDS (PLWHA) in Taiwan during 2000-2012. Methods The Taiwan National Health Insurance Research Database was used to identify PLWHA. The incidence densities of systemic and organ-specific autoimmune diseases were calculated, and age-Adjusted, sex-Adjusted and period-Adjusted standardised incidence rates (SIRs) were obtained by using two million people from the general population as controls. To examine the effects of highly active antiretroviral therapy (HAART) on the incidence of autoimmune diseases, the incidence densities and SIRs of autoimmune diseases were calculated after stratifying PLWHA by HAART status. Results Of the 20â €..444 PLWHA identified, the overall mean (SD) age was 30.1 (11.0) years; 67.2% of the subjects received HAART. As compared with the general population, SIRs were higher for incident Sjögren syndrome (SIR=1.64; 95% CI 1.24 to 2.13), psoriasis (SIR=2.05; 95% CI 1.67 to 2.48), systemic lupus erythematosus (SLE) (SIR=2.59; 95% CI 1.53 to 4.09), autoimmune haemolytic anaemia (SIR=35.06; 95% CI 23.1 to 51.02) and uveitis (SIR=2.50; 95% CI 2.05 to 3.02), but were lower for incident ankylosing spondyloarthritis (SIR=0.70; 95% CI 0.48 to 0.99). When the effect of HAART on incident autoimmune diseases was considered, PLWHA who received HAART had higher SIRs for psoriasis, autoimmune haemolytic anaemia and uveitis, but had lower risks of rheumatoid arthritis (RA) and ankylosing spondyloarthritis. In contrast, PLWHA who did not receive HAART had higher SIRs for Sjögren syndrome, psoriasis, RA, SLE, scleroderma, polymyositis, autoimmune haemolytic anaemia and Hashimoto's thyroiditis. Conclusions PLWHA had higher risks of incident Sjögren syndrome, psoriasis, SLE, autoimmune haemolytic anaemia and uveitis.

AB - Objectives It is not known if the incidences of autoimmune diseases are higher in individuals living with HIV infection or AIDS. Our study investigated the incidences of autoimmune diseases among people living with HIV/AIDS (PLWHA) in Taiwan during 2000-2012. Methods The Taiwan National Health Insurance Research Database was used to identify PLWHA. The incidence densities of systemic and organ-specific autoimmune diseases were calculated, and age-Adjusted, sex-Adjusted and period-Adjusted standardised incidence rates (SIRs) were obtained by using two million people from the general population as controls. To examine the effects of highly active antiretroviral therapy (HAART) on the incidence of autoimmune diseases, the incidence densities and SIRs of autoimmune diseases were calculated after stratifying PLWHA by HAART status. Results Of the 20â €..444 PLWHA identified, the overall mean (SD) age was 30.1 (11.0) years; 67.2% of the subjects received HAART. As compared with the general population, SIRs were higher for incident Sjögren syndrome (SIR=1.64; 95% CI 1.24 to 2.13), psoriasis (SIR=2.05; 95% CI 1.67 to 2.48), systemic lupus erythematosus (SLE) (SIR=2.59; 95% CI 1.53 to 4.09), autoimmune haemolytic anaemia (SIR=35.06; 95% CI 23.1 to 51.02) and uveitis (SIR=2.50; 95% CI 2.05 to 3.02), but were lower for incident ankylosing spondyloarthritis (SIR=0.70; 95% CI 0.48 to 0.99). When the effect of HAART on incident autoimmune diseases was considered, PLWHA who received HAART had higher SIRs for psoriasis, autoimmune haemolytic anaemia and uveitis, but had lower risks of rheumatoid arthritis (RA) and ankylosing spondyloarthritis. In contrast, PLWHA who did not receive HAART had higher SIRs for Sjögren syndrome, psoriasis, RA, SLE, scleroderma, polymyositis, autoimmune haemolytic anaemia and Hashimoto's thyroiditis. Conclusions PLWHA had higher risks of incident Sjögren syndrome, psoriasis, SLE, autoimmune haemolytic anaemia and uveitis.

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