Incidence, mortality, and causes of death of patients with pemphigus in Taiwan: A nationwide population-based study

Yu Huei Huang, Chang Fu Kuo, Yi Hua Chen, Ya-Wen Yang

研究成果: 雜誌貢獻文章

43 引文 (Scopus)

摘要

Pemphigus is a potentially life-threatening autoimmune blistering disease. However, little is known about the all-cause and cause-specific mortality among patients with pemphigus compared with the general population. The incidence of pemphigus in Taiwan has not been described previously. The objective of this study was to estimate the incidence of pemphigus in Taiwan and to investigate the overall mortality, causes of death, and cause-specific mortality in a nationwide population-based cohort of pemphigus patients. The study cohort included 853 patients newly diagnosed with pemphigus between 2002 and 2009 in the National Health Insurance Research Database. Survival status, date of death, and cause of death were ascertained by linking the study cohort with the National Register of Deaths Database of Taiwan. All-cause and cause-specific standardized mortality ratios (SMRs) were estimated. The incidence of pemphigus in Taiwan was 4.7 (95% confidence interval (CI), 3.2-6.2) per million per year. Overall, 88 deaths were observed during a mean follow-up period of 3.8 years, which was more than two times the number expected (SMR, 2.36; 95% confidence interval, 1.92-2.91). In the analysis of causes of death, the SMRs for death due to pneumonia (3.64; 95% CI, 1.30-10.21), septicemia (11.57; 95% CI, 2.95-45.34), cardiovascular disease (2.69; 95% CI, 1.18-6.12), and peptic ulcer disease (8.44; 95% CI, 1.22-58.21) were significantly higher than expected. We concluded that the incidence of pemphigus is not low in Taiwan, and the overall mortality among pemphigus patients is two times greater than that of the general population. In particular, patients with pemphigus have higher risk of mortality from systemic and respiratory tract infections, cardiovascular disease, and peptic ulcer disease.
原文英語
頁(從 - 到)92-97
頁數6
期刊Journal of Investigative Dermatology
132
發行號1
DOIs
出版狀態已發佈 - 一月 2012

指紋

Pemphigus
Taiwan
Cause of Death
Mortality
Incidence
Population
Confidence Intervals
Health insurance
Peptic Ulcer
Cohort Studies
Cardiovascular Diseases
Databases
National Health Programs
Respiratory Tract Infections
Autoimmune Diseases
Sepsis
Pneumonia

ASJC Scopus subject areas

  • Dermatology
  • Biochemistry
  • Cell Biology
  • Molecular Biology

引用此文

Incidence, mortality, and causes of death of patients with pemphigus in Taiwan : A nationwide population-based study. / Huang, Yu Huei; Kuo, Chang Fu; Chen, Yi Hua; Yang, Ya-Wen.

於: Journal of Investigative Dermatology, 卷 132, 編號 1, 01.2012, p. 92-97.

研究成果: 雜誌貢獻文章

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abstract = "Pemphigus is a potentially life-threatening autoimmune blistering disease. However, little is known about the all-cause and cause-specific mortality among patients with pemphigus compared with the general population. The incidence of pemphigus in Taiwan has not been described previously. The objective of this study was to estimate the incidence of pemphigus in Taiwan and to investigate the overall mortality, causes of death, and cause-specific mortality in a nationwide population-based cohort of pemphigus patients. The study cohort included 853 patients newly diagnosed with pemphigus between 2002 and 2009 in the National Health Insurance Research Database. Survival status, date of death, and cause of death were ascertained by linking the study cohort with the National Register of Deaths Database of Taiwan. All-cause and cause-specific standardized mortality ratios (SMRs) were estimated. The incidence of pemphigus in Taiwan was 4.7 (95{\%} confidence interval (CI), 3.2-6.2) per million per year. Overall, 88 deaths were observed during a mean follow-up period of 3.8 years, which was more than two times the number expected (SMR, 2.36; 95{\%} confidence interval, 1.92-2.91). In the analysis of causes of death, the SMRs for death due to pneumonia (3.64; 95{\%} CI, 1.30-10.21), septicemia (11.57; 95{\%} CI, 2.95-45.34), cardiovascular disease (2.69; 95{\%} CI, 1.18-6.12), and peptic ulcer disease (8.44; 95{\%} CI, 1.22-58.21) were significantly higher than expected. We concluded that the incidence of pemphigus is not low in Taiwan, and the overall mortality among pemphigus patients is two times greater than that of the general population. In particular, patients with pemphigus have higher risk of mortality from systemic and respiratory tract infections, cardiovascular disease, and peptic ulcer disease.",
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