Incidence and risk of major heart diseases in middle-aged adults with moderate to severe vision impairment

A population-based cohort study

Chun Mei Hsueh, Jing Hwa Wey, Jong Shiuan Yeh, Chien Hua Wu, Tsan Hon Liou, Kwang Hwa Chang

研究成果: 雜誌貢獻文章

摘要

Background/aim: To estimate the incidence and risk of major adverse cardiovascular events (MACEs), including heart failure and ischaemic heart disease, among middle-aged people with a visual disability (VD). Methods: We used a national health insurance research database to conduct a population-based cohort study from 1 January 2000 to 31 December 2013. Patients with VD aged 35∼65 years were recruited. For each VD patient, five age-matched, sex-matched and comorbidity-matched patients were randomly selected and recruited as controls. Control patients had no documented disability. Results: This study recruited 978 patients with VD (mean age±SD, 55.1±7.8 years; 48.9% male) and 4677 controls. Compared with the same sex of the controls, women with VD had higher incidence of MACE 1 (7.9 vs 2.8/1000 person-years, p<0.001), MACE 2 (27.5 vs 16.9/1000 person-years, p<0.001), MACE 3 (3.7 vs 1.4/1000 person-years, p<0.005) and MACE 4 (4.5 vs 2.5/1000 person-years, p<0.05), and men with VD had higher incidence of MACE 1 (4.6 vs 2.0/1000 person-years, p<0.005). Compared with the controls, patients with VD had lower cumulative MACE 1∼MACE 4-free probabilities and had an independently higher risk of MACE 1∼MACE 4 during the 13-year study, yielding an adjusted hazard ratio range of 1.31∼2.75. Those persons with VD who had diabetes and hypertension had greater risks of MACE 1∼MACE 4. Conclusions: Middle-aged adults with VD were at risk of MACEs. A programme for MACE prevention is important for middle-aged people with VD. This is especially true for women and for those who also have diabetes and hypertension.
原文英語
期刊British Journal of Ophthalmology
DOIs
出版狀態接受/付印 - 一月 1 2018

指紋

Heart Diseases
Cohort Studies
Incidence
Population
Disabled Persons
Hypertension
National Health Programs
Myocardial Ischemia
Comorbidity
Heart Failure
Databases
Research

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

引用此文

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title = "Incidence and risk of major heart diseases in middle-aged adults with moderate to severe vision impairment: A population-based cohort study",
abstract = "Background/aim: To estimate the incidence and risk of major adverse cardiovascular events (MACEs), including heart failure and ischaemic heart disease, among middle-aged people with a visual disability (VD). Methods: We used a national health insurance research database to conduct a population-based cohort study from 1 January 2000 to 31 December 2013. Patients with VD aged 35∼65 years were recruited. For each VD patient, five age-matched, sex-matched and comorbidity-matched patients were randomly selected and recruited as controls. Control patients had no documented disability. Results: This study recruited 978 patients with VD (mean age±SD, 55.1±7.8 years; 48.9{\%} male) and 4677 controls. Compared with the same sex of the controls, women with VD had higher incidence of MACE 1 (7.9 vs 2.8/1000 person-years, p<0.001), MACE 2 (27.5 vs 16.9/1000 person-years, p<0.001), MACE 3 (3.7 vs 1.4/1000 person-years, p<0.005) and MACE 4 (4.5 vs 2.5/1000 person-years, p<0.05), and men with VD had higher incidence of MACE 1 (4.6 vs 2.0/1000 person-years, p<0.005). Compared with the controls, patients with VD had lower cumulative MACE 1∼MACE 4-free probabilities and had an independently higher risk of MACE 1∼MACE 4 during the 13-year study, yielding an adjusted hazard ratio range of 1.31∼2.75. Those persons with VD who had diabetes and hypertension had greater risks of MACE 1∼MACE 4. Conclusions: Middle-aged adults with VD were at risk of MACEs. A programme for MACE prevention is important for middle-aged people with VD. This is especially true for women and for those who also have diabetes and hypertension.",
keywords = "heart failure, incidence, ischemic heart disease, vision disability",
author = "Hsueh, {Chun Mei} and Wey, {Jing Hwa} and Yeh, {Jong Shiuan} and Wu, {Chien Hua} and Liou, {Tsan Hon} and Chang, {Kwang Hwa}",
year = "2018",
month = "1",
day = "1",
doi = "10.1136/bjophthalmol-2018-312471",
language = "English",
journal = "British Journal of Ophthalmology",
issn = "0007-1161",
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TY - JOUR

T1 - Incidence and risk of major heart diseases in middle-aged adults with moderate to severe vision impairment

T2 - A population-based cohort study

AU - Hsueh, Chun Mei

AU - Wey, Jing Hwa

AU - Yeh, Jong Shiuan

AU - Wu, Chien Hua

AU - Liou, Tsan Hon

AU - Chang, Kwang Hwa

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background/aim: To estimate the incidence and risk of major adverse cardiovascular events (MACEs), including heart failure and ischaemic heart disease, among middle-aged people with a visual disability (VD). Methods: We used a national health insurance research database to conduct a population-based cohort study from 1 January 2000 to 31 December 2013. Patients with VD aged 35∼65 years were recruited. For each VD patient, five age-matched, sex-matched and comorbidity-matched patients were randomly selected and recruited as controls. Control patients had no documented disability. Results: This study recruited 978 patients with VD (mean age±SD, 55.1±7.8 years; 48.9% male) and 4677 controls. Compared with the same sex of the controls, women with VD had higher incidence of MACE 1 (7.9 vs 2.8/1000 person-years, p<0.001), MACE 2 (27.5 vs 16.9/1000 person-years, p<0.001), MACE 3 (3.7 vs 1.4/1000 person-years, p<0.005) and MACE 4 (4.5 vs 2.5/1000 person-years, p<0.05), and men with VD had higher incidence of MACE 1 (4.6 vs 2.0/1000 person-years, p<0.005). Compared with the controls, patients with VD had lower cumulative MACE 1∼MACE 4-free probabilities and had an independently higher risk of MACE 1∼MACE 4 during the 13-year study, yielding an adjusted hazard ratio range of 1.31∼2.75. Those persons with VD who had diabetes and hypertension had greater risks of MACE 1∼MACE 4. Conclusions: Middle-aged adults with VD were at risk of MACEs. A programme for MACE prevention is important for middle-aged people with VD. This is especially true for women and for those who also have diabetes and hypertension.

AB - Background/aim: To estimate the incidence and risk of major adverse cardiovascular events (MACEs), including heart failure and ischaemic heart disease, among middle-aged people with a visual disability (VD). Methods: We used a national health insurance research database to conduct a population-based cohort study from 1 January 2000 to 31 December 2013. Patients with VD aged 35∼65 years were recruited. For each VD patient, five age-matched, sex-matched and comorbidity-matched patients were randomly selected and recruited as controls. Control patients had no documented disability. Results: This study recruited 978 patients with VD (mean age±SD, 55.1±7.8 years; 48.9% male) and 4677 controls. Compared with the same sex of the controls, women with VD had higher incidence of MACE 1 (7.9 vs 2.8/1000 person-years, p<0.001), MACE 2 (27.5 vs 16.9/1000 person-years, p<0.001), MACE 3 (3.7 vs 1.4/1000 person-years, p<0.005) and MACE 4 (4.5 vs 2.5/1000 person-years, p<0.05), and men with VD had higher incidence of MACE 1 (4.6 vs 2.0/1000 person-years, p<0.005). Compared with the controls, patients with VD had lower cumulative MACE 1∼MACE 4-free probabilities and had an independently higher risk of MACE 1∼MACE 4 during the 13-year study, yielding an adjusted hazard ratio range of 1.31∼2.75. Those persons with VD who had diabetes and hypertension had greater risks of MACE 1∼MACE 4. Conclusions: Middle-aged adults with VD were at risk of MACEs. A programme for MACE prevention is important for middle-aged people with VD. This is especially true for women and for those who also have diabetes and hypertension.

KW - heart failure

KW - incidence

KW - ischemic heart disease

KW - vision disability

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