Inactivation of lytic transglycosylases increases susceptibility to aminoglycosides and macrolides by altering the outer membrane permeability of Stenotrophomonas maltophilia

Chao Jung Wu, Yi Wei Huang, Yi Tsung Lin, Tsuey Ching Yang

研究成果: 雜誌貢獻文章同行評審

11 引文 斯高帕斯(Scopus)

摘要

Stenotrophomonas maltophilia harbors six lytic transglycosylases (LTs): mltA, mltB1, mltB2, mltD1, mltD2, and slt. LT deletion increased susceptibility of S. maltophilia to aminoglycosides (AGs) and macrolides, and the underlying mechanisms were investigated. The expression of AG-modifying enzymes and efflux pumps was evaluated by quantitative reverse transcription-PCR (qRT-PCR). Susceptibility to 1-N-phenylnaphthylamine, vancomycin, SDS, and bile salts was measured to assess outer membrane permeability. In conclusion, increased outer membrane permeability contributes to LT deletion-mediated increase in aminoglycoside and macrolide susceptibility.
原文英語
頁(從 - 到)3236-3239
頁數4
期刊Antimicrobial Agents and Chemotherapy
60
發行號5
DOIs
出版狀態已發佈 - 5月 2016
對外發佈

ASJC Scopus subject areas

  • 藥理
  • 藥學(醫學)
  • 傳染性疾病

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