In vivo investigation into effectiveness of Fe3O4/PLLA nanofibers for bone tissue engineering applications

Wei Yi Lai, Sheng Wei Feng, Ya Hui Chan, Wei Jen Chang, Hsin Ta Wang, Haw Ming Huang

研究成果: 雜誌貢獻文章同行評審

16 引文 斯高帕斯(Scopus)


Fe3O4 nanoparticles were loaded into poly-L-lactide (PLLA) with concentrations of 2% and 5%, respectively, using an electrospinning method. In vivo animal experiments were then performed to evaluate the potential of the Fe3O4/PLLA nanofibrous material for bone tissue engineering applications. Bony defects with a diameter of 4 mm were prepared in rabbit tibias. Fe3O4/PLLA nanofibers were grafted into the drilled defects and histological examination and computed tomography (CT) image detection were performed after an eight-week healing period. The histological results showed that the artificial bony defects grafted with Fe3O4/PLLA nanofibers exhibited a visibly higher bone healing activity than those grafted with neat PLLA. In addition, the quantitative results from CT images revealed that the bony defects grafted with 2% and 5% Fe3O4/PLLA nanofibers, respectively, showed 1.9-and 2.3-fold increases in bone volume compared to the control blank sample. Overall, the results suggest that the Fe3O4/PLLA nanofibers fabricated in this study may serve as a useful biomaterial for future bone tissue engineering applications.
出版狀態已發佈 - 七月 22 2018

ASJC Scopus subject areas

  • 化學 (全部)
  • 聚合物和塑料


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