In vivo biological response to highly cross-linked and vitamin e-doped polyethylene - A particle-Induced osteolysis animal study

Chang Hung Huang, Yung Chang Lu, Ting Kuo Chang, I. Lin Hsiao, Yi Ching Su, Shu Ting Yeh, Hsu Wei Fang, Chun Hsiung Huang

研究成果: 雜誌貢獻文章同行評審

11 引文 斯高帕斯(Scopus)

摘要

Polyethylene particle-induced osteolysis is the primary limitation in the long-term success of total joint replacement with conventional ultra high molecular weight polyethylene (UHMWPE). Highly cross-linked polyethylene (HXLPE) and vitamin E-doped cross-linked polyethylene (VE-HXLPE) have been developed to increase the wear resistance of joint surfaces. However, very few studies have reported on the incidence of particle-induced osteolysis for these novel materials. The aim of this study was to use a particle-induced osteolysis animal model to compare the in vivo biological response to different polymer particles. Three commercially available polymers (UHMWPE, HXLPE, and VE-HXLPE) were compared. Osseous properties including the bone volume relative to the tissue volume (BV/TV), trabecular thickness (Tb. Th), and bone mineral density (BMD) were examined using micro computed tomography. Histological analysis was used to observe tissue inflammation in each group. This study demonstrated that the osseous properties and noticeable inflammatory reactions were obviously decreased in the HXLPE group. When compared with the sham group, a decrease of 12.7% was found in BV/TV, 9.6% in BMD and 8.3% in Tb.Th for the HXLPE group. The heightened inflammatory response in the HXLPE group could be due to its smaller size and greater amount of implanted particles. Vitamin E diffused in vivo may not affect the inflammatory and osteolytic responses in this model. The morphological size and total cumulative amount of implanted particles could be critical factors in determining the biological response.
原文英語
頁(從 - 到)561-567
頁數7
期刊Journal of Biomedical Materials Research - Part B Applied Biomaterials
104
發行號3
DOIs
出版狀態已發佈 - 四月 1 2016
對外發佈

ASJC Scopus subject areas

  • 生物材料
  • 生物醫學工程

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