In vivo and in vitro anti-tumor effects of fungal extracts

Hung Tsung Wu, Feng Hwa Lu, Yu Chu Su, Horng Yih Ou, Hao Chang Hung, Jin Shang Wu, Yi Ching Yang, Chih Jen Chang

研究成果: 雜誌貢獻文章

18 引文 (Scopus)

摘要

Fungal extracts are extensively used as nutritional supplements in Far-Eastern Asia. In this study, we aimed to evaluate the anti-cancer activities of some different fungal species against different cancer cell lines. The water or ethanol extracts of Fomitopsis pinicola (F. pinicola), Ganoderma sinense, Fomitopsis officinalis, Polyporus melanopus, and Taiwanofungus camphorates were used to evaluate the anti-cancer activities in various cancer cells. We found that all of the fungi ethanol extracts used in this study exert anti-cancer activities in vitro, whereas water extracts show lower inhibitory activities as determined by 3-(4,5-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Among the tested fungi species, F. pinicola ethanol extract exerts the most significant anti-cancer activity (growth inhibitory ratio 82.8%, p < 0.001) by increasing cell apoptosis. Moreover, F. pinicola ethanol extract significantly decreased tumor size (tumor growth inhibitory ratio 54%, p < 0.05) and increased the lifespan in mice bearing sarcoma-180 tumors. Taken together, this is the first study indicating the anti-tumor effect of F. pinicola in vivo and in vitro. F. pinicola ethanol extract induces cell apoptosis to exert a significant anti-tumor activity, with potential to be a new alternative anti-tumor medicine.
原文英語
頁(從 - 到)2546-2556
頁數11
期刊Molecules
19
發行號2
DOIs
出版狀態已發佈 - 二月 1 2014
對外發佈Yes

指紋

Tumors
tumors
Coriolaceae
cancer
Ethanol
ethyl alcohol
Neoplasms
Fungi
fungi
apoptosis
Bearings (structural)
Cells
Apoptosis
Water
Bioelectric potentials
Bromides
supplements
Medicine
In Vitro Techniques
cells

ASJC Scopus subject areas

  • Organic Chemistry

引用此文

Wu, H. T., Lu, F. H., Su, Y. C., Ou, H. Y., Hung, H. C., Wu, J. S., ... Chang, C. J. (2014). In vivo and in vitro anti-tumor effects of fungal extracts. Molecules, 19(2), 2546-2556. https://doi.org/10.3390/molecules19022546

In vivo and in vitro anti-tumor effects of fungal extracts. / Wu, Hung Tsung; Lu, Feng Hwa; Su, Yu Chu; Ou, Horng Yih; Hung, Hao Chang; Wu, Jin Shang; Yang, Yi Ching; Chang, Chih Jen.

於: Molecules, 卷 19, 編號 2, 01.02.2014, p. 2546-2556.

研究成果: 雜誌貢獻文章

Wu, HT, Lu, FH, Su, YC, Ou, HY, Hung, HC, Wu, JS, Yang, YC & Chang, CJ 2014, 'In vivo and in vitro anti-tumor effects of fungal extracts', Molecules, 卷 19, 編號 2, 頁 2546-2556. https://doi.org/10.3390/molecules19022546
Wu HT, Lu FH, Su YC, Ou HY, Hung HC, Wu JS 等. In vivo and in vitro anti-tumor effects of fungal extracts. Molecules. 2014 2月 1;19(2):2546-2556. https://doi.org/10.3390/molecules19022546
Wu, Hung Tsung ; Lu, Feng Hwa ; Su, Yu Chu ; Ou, Horng Yih ; Hung, Hao Chang ; Wu, Jin Shang ; Yang, Yi Ching ; Chang, Chih Jen. / In vivo and in vitro anti-tumor effects of fungal extracts. 於: Molecules. 2014 ; 卷 19, 編號 2. 頁 2546-2556.
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