In vitro immunomodulatory effects of cuphiin D1 on human mononuclear cells

Ching Chiung Wang, Lih Geeng Chen, Ling-Ling Yang

研究成果: 雜誌貢獻文章同行評審

12 引文 斯高帕斯(Scopus)


Cuphiin D1 (CD1), a macrocyclic hydrolyzable tannin isolated from Cuphea hyssopifolia, has been shown to exert antitumor activity both in vitro and in vivo. Moreover, the antitumor effects of CD1 are not only related to its cytotoxicity to carcinoma cell lines, but also depend on host-mediated mechanisms. In the present study, CD1 was investigated for its effects on the proliferation and cytokine secretion of human peripheral blood mononuclear cells (PBMCs). At concentrations of from 6.25 to 50 μg/ml, it enhanced the 3H-thymidine incorporation of concanavalin A (Con A)-stimulated PBMCs in a dose-dependent manner. Excretion of IL-1β, IL-2 and TNF-α by CD1-stimulated PBMCs was markedly increased in a dose-dependent manner. The results show that CD1 could stimulate PBMCs release of IL-1β, IL-2 and TNF-α and then activate T cells. Therefore, CD1-activated T cells via IL-1β in vitro might account for the host-mediated CD1 mechanism of action.

頁(從 - 到)4233-4236
期刊Anticancer Research
發行號6 C
出版狀態已發佈 - 11月 2002

ASJC Scopus subject areas

  • 癌症研究
  • 腫瘤科


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