In Vitro efficacies and resistance profiles of rifampin-based combination regimens for biofilm-embedded methicillin-resistant Staphylococcus aureus

Hung Jen Tang, Chi Chung Chen, Kuo Chen Cheng, Kuan Ying Wu, Yi Chung Lin, Chun Cheng Zhang, Tzu Chieh Weng, Wen Liang Yu, Yu Hsin Chiu, Han Siong Toh, Shyh Ren Chiang, Bo An Su, Wen Chien Ko, Yin Ching Chuang

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40 引文 斯高帕斯(Scopus)

摘要

To compare the in vitro antibacterial efficacies and resistance profiles of rifampin-based combinations against methicillin-resistant Staphylococcus aureus (MRSA) in a biofilm model, the antibacterial activities of vancomycin, teicoplanin, daptomycin, minocycline, linezolid, fusidic acid, fosfomycin, and tigecycline alone or in combination with rifampin against biofilm-embedded MRSA were measured. The rifampin-resistant mutation frequencies were evaluated. Of the rifampin-based combinations, rifampin enhances the antibacterial activities of and even synergizes with fusidic acid, tigecycline, and, to a lesser extent, linezolid, fosfomycin, and minocycline against biofilm-embedded MRSA. Such combinations with weaker rifampin resistance induction activities may provide a therapeutic advantage in MRSA biofilm-related infections.

原文英語
頁(從 - 到)5717-5720
頁數4
期刊Antimicrobial Agents and Chemotherapy
57
發行號11
DOIs
出版狀態已發佈 - 十一月 2013
對外發佈Yes

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

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