In vitro biocompatibility, radiopacity, and physical property tests of nano-Fe3O4 incorporated poly-L-lactide bone screws

Hsin Ta Wang, Pao Chang Chiang, Jy Jiunn Tzeng, Ting Lin Wu, Yu Hwa Pan, Wei Jen Chang, Haw Ming Huang

研究成果: 雜誌貢獻文章同行評審

9 引文 斯高帕斯(Scopus)


The aim of this study was to fabricate biodegradable poly-L-lactic acid (PLLA) bone screws containing iron oxide (Fe3O4) nanoparticles, which are radiopaque and 3D-printable. The PLLA composites were fabricated by loading 20%, 30%, and 40% Fe3O4 nanoparticles into the PLLA. The physical properties, including elastic modulus, thermal properties, and biocompatibility of the composites were tested. The 20% nano-Fe3O4/PLLA composite was used as the material for fabricating the 3D-printed bone screws. The mechanical performance of the nano-Fe3O4/PLLA bone screws was evaluated by anti-bending and anti-torque strength tests. The tissue response and radiopacity of the nano-Fe3O4/PLLA bone screws were assessed by histologic and CT imaging studies using an animal model. The addition of nano-Fe3O4 increased the crystallization of the PLLA composites. Furthermore, the 20% nano-Fe3O4/PLLA composite exhibited the highest thermal stability compared to the other Fe3O4 proportions. The 3D-printed bone screws using the 20% nano-Fe3O4/PLLA composite provided excellent local tissue response. In addition, the radiopacity of the 20% nano-Fe3O4/PLLA screw was significantly better compared with the neat PLLA screw.
出版狀態已發佈 - 六月 1 2017

ASJC Scopus subject areas

  • 化學 (全部)
  • 聚合物和塑料


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