TY - JOUR
T1 - In vitro biocompatibility, radiopacity, and physical property tests of nano-Fe3O4 incorporated poly-L-lactide bone screws
AU - Wang, Hsin Ta
AU - Chiang, Pao Chang
AU - Tzeng, Jy Jiunn
AU - Wu, Ting Lin
AU - Pan, Yu Hwa
AU - Chang, Wei Jen
AU - Huang, Haw Ming
PY - 2017/6/1
Y1 - 2017/6/1
N2 - The aim of this study was to fabricate biodegradable poly-L-lactic acid (PLLA) bone screws containing iron oxide (Fe3O4) nanoparticles, which are radiopaque and 3D-printable. The PLLA composites were fabricated by loading 20%, 30%, and 40% Fe3O4 nanoparticles into the PLLA. The physical properties, including elastic modulus, thermal properties, and biocompatibility of the composites were tested. The 20% nano-Fe3O4/PLLA composite was used as the material for fabricating the 3D-printed bone screws. The mechanical performance of the nano-Fe3O4/PLLA bone screws was evaluated by anti-bending and anti-torque strength tests. The tissue response and radiopacity of the nano-Fe3O4/PLLA bone screws were assessed by histologic and CT imaging studies using an animal model. The addition of nano-Fe3O4 increased the crystallization of the PLLA composites. Furthermore, the 20% nano-Fe3O4/PLLA composite exhibited the highest thermal stability compared to the other Fe3O4 proportions. The 3D-printed bone screws using the 20% nano-Fe3O4/PLLA composite provided excellent local tissue response. In addition, the radiopacity of the 20% nano-Fe3O4/PLLA screw was significantly better compared with the neat PLLA screw.
AB - The aim of this study was to fabricate biodegradable poly-L-lactic acid (PLLA) bone screws containing iron oxide (Fe3O4) nanoparticles, which are radiopaque and 3D-printable. The PLLA composites were fabricated by loading 20%, 30%, and 40% Fe3O4 nanoparticles into the PLLA. The physical properties, including elastic modulus, thermal properties, and biocompatibility of the composites were tested. The 20% nano-Fe3O4/PLLA composite was used as the material for fabricating the 3D-printed bone screws. The mechanical performance of the nano-Fe3O4/PLLA bone screws was evaluated by anti-bending and anti-torque strength tests. The tissue response and radiopacity of the nano-Fe3O4/PLLA bone screws were assessed by histologic and CT imaging studies using an animal model. The addition of nano-Fe3O4 increased the crystallization of the PLLA composites. Furthermore, the 20% nano-Fe3O4/PLLA composite exhibited the highest thermal stability compared to the other Fe3O4 proportions. The 3D-printed bone screws using the 20% nano-Fe3O4/PLLA composite provided excellent local tissue response. In addition, the radiopacity of the 20% nano-Fe3O4/PLLA screw was significantly better compared with the neat PLLA screw.
KW - 3D printed bone screw
KW - Iron oxide nanoparticles
KW - Poly-L-lactic acid
KW - Radiopaque polymer
UR - http://www.scopus.com/inward/record.url?scp=85020245572&partnerID=8YFLogxK
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U2 - 10.3390/polym9060191
DO - 10.3390/polym9060191
M3 - Article
AN - SCOPUS:85020245572
VL - 9
JO - Polymers
JF - Polymers
SN - 2073-4360
IS - 6
M1 - 191
ER -