In vitro antimicrobial and anticancer potential of hinokitiol against oral pathogens and oral cancer cell lines

Yin Hua Shih, Kuo Wei Chang, Shih Min Hsia, Cheng Chia Yu, Lih Jyh Fuh, Tzu Yun Chi, Tzong Ming Shieh

研究成果: 雜誌貢獻文章

42 引文 斯高帕斯(Scopus)

摘要

Hinokitiol is a natural component isolated from Chamacyparis taiwanensis. It has anti-microbial activity, and has been used in oral care products. The minimal inhibitory concentration (MIC) and minimal microbicidal concentration (MMC) of hinokitiol against MRSA, Aggregatibacter actinomycetemcomitans, Streptococcus mutans, and Candida albicans were determined by the agar and broth dilution method (MIC: 40-110. μM; MMC: 50-130. μM); the paradoxical inhibition phenomenon (PIP) was observed in A. actinomycetemcomitans and S. mutans. The PIP can be described as microbial growth occurring in the presence of both high and low concentrations of a compound, between which microbial growth is inhibited. The PIP was confirmed using a kinetic microplate and inhibition zone methods. The PIP was also observed in MRSA. The low autolysin activity somehow correlated to the PIP positive. The cell diameter was increased in all the pathogens, and the transition was inhibited in C. albicans following hinokitiol treatment. Hinokitiol is also a potential anticancer drug. The 200. μM of hinokitiol has significant antimicrobial and cytotoxic activities against oral pathogens and oral squamous cell carcinoma cell lines, respectively, and lower cytotoxic effects for normal human oral keratinocytes, indicating that hinokitiol displays a high potential for safe and effective applications in oral health care.

原文英語
頁(從 - 到)254-262
頁數9
期刊Microbiological Research
168
發行號5
DOIs
出版狀態已發佈 - 六月 12 2013

ASJC Scopus subject areas

  • Microbiology

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