摘要
Fifteen crude drugs, Stellaria media Cyrill. (Caryophyllaceae), Calendula officinalis L. (Compositae), Achillea millefolium L. (Compositae), Verbascum thapsus L. (Scrophulariaceae), Plantago major L. (Plantaginaceae), Borago officinalis L. (Boraginaceae), Satureja hortensis L. (Labiatae), Coptis groenlandica Salisb. (Ranunculaceae), Cassia angustifolia Vahl. (Leguminosae), Origanum majorana L. (Labiatae), Centella asiatica L. (Umbelliferae), Caulophyllum thalictroides Mich. (Berberidaceae), Picea rubens Sargent. (Pinaceae), Rhamnus purshiana D.C. (Rhamnaceae) and Hibiscus sabdariffa L. (Malvaceae), which have been used as folk medicine in Canada, were evaluated for their anti-hepatoma activity on five human liver-cancer cell lines, i.e. HepG2/C3A, SK-HEP-1, HA22T/VGH, Hep3B and PLC/PRF/5. The samples were examined by in vitro evaluation for their cytotoxicity. The results showed that the effects of crude drugs on hepatitis B virus genome-containing cell lines were different from those against non hepatitis B virus genome-containing cell lines. C. groenlandica was observed to be the most effective against the growth of all five cell lines and its chemotherapeutic values will be of interest for further studies.
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 440-444 |
| 頁數 | 5 |
| 期刊 | Phytotherapy Research |
| 卷 | 16 |
| 發行號 | 5 |
| DOIs | |
| 出版狀態 | 已發佈 - 八月 2002 |
| 對外發佈 | Yes |
指紋
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry
- Pharmacology
引用此文
In vitro anti-hepatoma activity of fifteen natural medicines from Canada. / Lin, Liang Tzung; Liu, Li Teh; Chiang, Lien Chai; Lin, Chun Ching.
於: Phytotherapy Research, 卷 16, 編號 5, 08.2002, p. 440-444.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - In vitro anti-hepatoma activity of fifteen natural medicines from Canada
AU - Lin, Liang Tzung
AU - Liu, Li Teh
AU - Chiang, Lien Chai
AU - Lin, Chun Ching
PY - 2002/8
Y1 - 2002/8
N2 - Fifteen crude drugs, Stellaria media Cyrill. (Caryophyllaceae), Calendula officinalis L. (Compositae), Achillea millefolium L. (Compositae), Verbascum thapsus L. (Scrophulariaceae), Plantago major L. (Plantaginaceae), Borago officinalis L. (Boraginaceae), Satureja hortensis L. (Labiatae), Coptis groenlandica Salisb. (Ranunculaceae), Cassia angustifolia Vahl. (Leguminosae), Origanum majorana L. (Labiatae), Centella asiatica L. (Umbelliferae), Caulophyllum thalictroides Mich. (Berberidaceae), Picea rubens Sargent. (Pinaceae), Rhamnus purshiana D.C. (Rhamnaceae) and Hibiscus sabdariffa L. (Malvaceae), which have been used as folk medicine in Canada, were evaluated for their anti-hepatoma activity on five human liver-cancer cell lines, i.e. HepG2/C3A, SK-HEP-1, HA22T/VGH, Hep3B and PLC/PRF/5. The samples were examined by in vitro evaluation for their cytotoxicity. The results showed that the effects of crude drugs on hepatitis B virus genome-containing cell lines were different from those against non hepatitis B virus genome-containing cell lines. C. groenlandica was observed to be the most effective against the growth of all five cell lines and its chemotherapeutic values will be of interest for further studies.
AB - Fifteen crude drugs, Stellaria media Cyrill. (Caryophyllaceae), Calendula officinalis L. (Compositae), Achillea millefolium L. (Compositae), Verbascum thapsus L. (Scrophulariaceae), Plantago major L. (Plantaginaceae), Borago officinalis L. (Boraginaceae), Satureja hortensis L. (Labiatae), Coptis groenlandica Salisb. (Ranunculaceae), Cassia angustifolia Vahl. (Leguminosae), Origanum majorana L. (Labiatae), Centella asiatica L. (Umbelliferae), Caulophyllum thalictroides Mich. (Berberidaceae), Picea rubens Sargent. (Pinaceae), Rhamnus purshiana D.C. (Rhamnaceae) and Hibiscus sabdariffa L. (Malvaceae), which have been used as folk medicine in Canada, were evaluated for their anti-hepatoma activity on five human liver-cancer cell lines, i.e. HepG2/C3A, SK-HEP-1, HA22T/VGH, Hep3B and PLC/PRF/5. The samples were examined by in vitro evaluation for their cytotoxicity. The results showed that the effects of crude drugs on hepatitis B virus genome-containing cell lines were different from those against non hepatitis B virus genome-containing cell lines. C. groenlandica was observed to be the most effective against the growth of all five cell lines and its chemotherapeutic values will be of interest for further studies.
KW - Anti-hepatoma activity
KW - Canada
KW - Crude drugs
KW - HBV
KW - Natural medicines
KW - Tumour
UR - http://www.scopus.com/inward/record.url?scp=0036667470&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036667470&partnerID=8YFLogxK
U2 - 10.1002/ptr.937
DO - 10.1002/ptr.937
M3 - Article
C2 - 12203264
AN - SCOPUS:0036667470
VL - 16
SP - 440
EP - 444
JO - Phytotherapy Research
JF - Phytotherapy Research
SN - 0951-418X
IS - 5
ER -