In vitro and in vivo evaluations of topically applied capsaicin and nonivamide from hydrogels

Ying Y. Wang, Chi Tzong Hong, Wen T. Chiu, Jia Y. Fang

研究成果: 雜誌貢獻文章

81 引文 (Scopus)

摘要

The purpose of this study was designed to investigate the in vitro and in vivo skin absorption of capsaicin and nonivamide from hydrogels. Various commercialized creams of capsaicin were also compared with hydrogels. Both skin stripping technique and Mexameter® were applied to evaluate the level of capsaicin and nonivamide retained in stratum corneum (SC) and skin erythema in vivo. The partition of drug between skin and the hydrogel matrix was considered to play an important role in the permeation process. The in vitro permeation of capsaicin from hydrogels depends on the physicochemical nature and the concentration of the polymer used. The incorporation of nonionic Pluronic F-127 polymer into hydrogels resulted in a retarded release of capsaicin. On the other hand, the in vitro capsaicin permeation showed higher levels in cationic chitosan and anionic carboxymethyl cellulose (CMC) hydrogels than cream bases. The permeation of nonivamide was retarded at the late stage of in vitro application. The inter-subject variation was more significant in the in vivo study than in vitro skin permeation experiments. The cream induced in vivo skin erythema depending on the drug concentration, however, the dose-dependence was not observed in hydrogels. Nonivamide-treated skin showed stronger erythema than capsaicin-treated skin. The present study indicates that there is a moderate correlation between in vitro skin permeation and in vivo erythema responses of topically applied capsaicin and nonivamide. The correlation between drug amount in SC and skin erythema test in vivo was also observed.

原文英語
頁(從 - 到)89-104
頁數16
期刊International Journal of Pharmaceutics
224
發行號1-2
DOIs
出版狀態已發佈 - 八月 14 2001

指紋

Hydrogels
Capsaicin
Erythema
Skin
Cornea
Polymers
Pharmaceutical Preparations
Skin Absorption
Poloxamer
Carboxymethylcellulose Sodium
In Vitro Techniques
nonivamide
Hydrogel
Chitosan
Skin Tests

ASJC Scopus subject areas

  • Pharmaceutical Science

引用此文

In vitro and in vivo evaluations of topically applied capsaicin and nonivamide from hydrogels. / Wang, Ying Y.; Hong, Chi Tzong; Chiu, Wen T.; Fang, Jia Y.

於: International Journal of Pharmaceutics, 卷 224, 編號 1-2, 14.08.2001, p. 89-104.

研究成果: 雜誌貢獻文章

Wang, Ying Y. ; Hong, Chi Tzong ; Chiu, Wen T. ; Fang, Jia Y. / In vitro and in vivo evaluations of topically applied capsaicin and nonivamide from hydrogels. 於: International Journal of Pharmaceutics. 2001 ; 卷 224, 編號 1-2. 頁 89-104.
@article{9b41bfb97d184165b8eebbc63b5377dc,
title = "In vitro and in vivo evaluations of topically applied capsaicin and nonivamide from hydrogels",
abstract = "The purpose of this study was designed to investigate the in vitro and in vivo skin absorption of capsaicin and nonivamide from hydrogels. Various commercialized creams of capsaicin were also compared with hydrogels. Both skin stripping technique and Mexameter{\circledR} were applied to evaluate the level of capsaicin and nonivamide retained in stratum corneum (SC) and skin erythema in vivo. The partition of drug between skin and the hydrogel matrix was considered to play an important role in the permeation process. The in vitro permeation of capsaicin from hydrogels depends on the physicochemical nature and the concentration of the polymer used. The incorporation of nonionic Pluronic F-127 polymer into hydrogels resulted in a retarded release of capsaicin. On the other hand, the in vitro capsaicin permeation showed higher levels in cationic chitosan and anionic carboxymethyl cellulose (CMC) hydrogels than cream bases. The permeation of nonivamide was retarded at the late stage of in vitro application. The inter-subject variation was more significant in the in vivo study than in vitro skin permeation experiments. The cream induced in vivo skin erythema depending on the drug concentration, however, the dose-dependence was not observed in hydrogels. Nonivamide-treated skin showed stronger erythema than capsaicin-treated skin. The present study indicates that there is a moderate correlation between in vitro skin permeation and in vivo erythema responses of topically applied capsaicin and nonivamide. The correlation between drug amount in SC and skin erythema test in vivo was also observed.",
keywords = "Capsaicin, Hydrogels, Nonivamide, Skin, Topical application",
author = "Wang, {Ying Y.} and Hong, {Chi Tzong} and Chiu, {Wen T.} and Fang, {Jia Y.}",
year = "2001",
month = "8",
day = "14",
doi = "10.1016/S0378-5173(01)00755-4",
language = "English",
volume = "224",
pages = "89--104",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - In vitro and in vivo evaluations of topically applied capsaicin and nonivamide from hydrogels

AU - Wang, Ying Y.

AU - Hong, Chi Tzong

AU - Chiu, Wen T.

AU - Fang, Jia Y.

PY - 2001/8/14

Y1 - 2001/8/14

N2 - The purpose of this study was designed to investigate the in vitro and in vivo skin absorption of capsaicin and nonivamide from hydrogels. Various commercialized creams of capsaicin were also compared with hydrogels. Both skin stripping technique and Mexameter® were applied to evaluate the level of capsaicin and nonivamide retained in stratum corneum (SC) and skin erythema in vivo. The partition of drug between skin and the hydrogel matrix was considered to play an important role in the permeation process. The in vitro permeation of capsaicin from hydrogels depends on the physicochemical nature and the concentration of the polymer used. The incorporation of nonionic Pluronic F-127 polymer into hydrogels resulted in a retarded release of capsaicin. On the other hand, the in vitro capsaicin permeation showed higher levels in cationic chitosan and anionic carboxymethyl cellulose (CMC) hydrogels than cream bases. The permeation of nonivamide was retarded at the late stage of in vitro application. The inter-subject variation was more significant in the in vivo study than in vitro skin permeation experiments. The cream induced in vivo skin erythema depending on the drug concentration, however, the dose-dependence was not observed in hydrogels. Nonivamide-treated skin showed stronger erythema than capsaicin-treated skin. The present study indicates that there is a moderate correlation between in vitro skin permeation and in vivo erythema responses of topically applied capsaicin and nonivamide. The correlation between drug amount in SC and skin erythema test in vivo was also observed.

AB - The purpose of this study was designed to investigate the in vitro and in vivo skin absorption of capsaicin and nonivamide from hydrogels. Various commercialized creams of capsaicin were also compared with hydrogels. Both skin stripping technique and Mexameter® were applied to evaluate the level of capsaicin and nonivamide retained in stratum corneum (SC) and skin erythema in vivo. The partition of drug between skin and the hydrogel matrix was considered to play an important role in the permeation process. The in vitro permeation of capsaicin from hydrogels depends on the physicochemical nature and the concentration of the polymer used. The incorporation of nonionic Pluronic F-127 polymer into hydrogels resulted in a retarded release of capsaicin. On the other hand, the in vitro capsaicin permeation showed higher levels in cationic chitosan and anionic carboxymethyl cellulose (CMC) hydrogels than cream bases. The permeation of nonivamide was retarded at the late stage of in vitro application. The inter-subject variation was more significant in the in vivo study than in vitro skin permeation experiments. The cream induced in vivo skin erythema depending on the drug concentration, however, the dose-dependence was not observed in hydrogels. Nonivamide-treated skin showed stronger erythema than capsaicin-treated skin. The present study indicates that there is a moderate correlation between in vitro skin permeation and in vivo erythema responses of topically applied capsaicin and nonivamide. The correlation between drug amount in SC and skin erythema test in vivo was also observed.

KW - Capsaicin

KW - Hydrogels

KW - Nonivamide

KW - Skin

KW - Topical application

UR - http://www.scopus.com/inward/record.url?scp=0035859975&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035859975&partnerID=8YFLogxK

U2 - 10.1016/S0378-5173(01)00755-4

DO - 10.1016/S0378-5173(01)00755-4

M3 - Article

C2 - 11472818

AN - SCOPUS:0035859975

VL - 224

SP - 89

EP - 104

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -