In vitro and in vivo anti-osteoarthritis effects of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside from Polygonum multiflorum

Po Wei Tsai, Yi Hui Lee, Lih Geeng Chen, Chia Jung Lee, Ching Chiung Wang

研究成果: 雜誌貢獻文章

3 引文 (Scopus)

摘要

Polygonum multiflorum Thunb. is a traditional herbal medicine that is rich in polyphenols. The major compound, 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (THSG) has many pharmacological activities, such as antioxidative and free radical-scavenging properties, and the abilities to reduce hyperlipidemia, prevent lipid peroxidation, and protect the cardiovascular system. In this study, the anti-osteoarthritis (OA) effects of THSG were explored using in vitro and in vivo models. THSG inhibited nitric oxide (NO) and prostaglandin E2 (PGE2) production and inducible NO synthase (iNOS) and cyclooxygenase-2 expressions by lipopolysaccharide-stimulated RAW 264.7 cells. On the other hand, THSG inhibited PGE2 production and iNOS and matrix metalloproteinase-13 expressions by interleukin-1β-stimulated primary rat chondrocytes. Through a mono-iodoacetate-induced rat OA model assay, THSG reduced paw edema and improved the weight-bearing distribution. Therefore, THSG has anti-inflammatory activity and could be applied as a lead compound for the development as an OA drug.
原文英語
文章編號571
期刊Molecules
23
發行號3
DOIs
出版狀態已發佈 - 一月 1 2018

指紋

prostaglandins
glucosides
nitric oxide
Dinoprostone
Osteoarthritis
rats
Rats
Bearings (structural)
Matrix Metalloproteinase 13
Iodoacetates
Lead compounds
interleukins
cardiovascular system
lead compounds
edema
Cardiovascular system
Scavenging
scavenging
Polyphenols
Nitric Oxide Synthase Type II

ASJC Scopus subject areas

  • Organic Chemistry

引用此文

In vitro and in vivo anti-osteoarthritis effects of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside from Polygonum multiflorum. / Tsai, Po Wei; Lee, Yi Hui; Chen, Lih Geeng; Lee, Chia Jung; Wang, Ching Chiung.

於: Molecules, 卷 23, 編號 3, 571, 01.01.2018.

研究成果: 雜誌貢獻文章

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abstract = "Polygonum multiflorum Thunb. is a traditional herbal medicine that is rich in polyphenols. The major compound, 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (THSG) has many pharmacological activities, such as antioxidative and free radical-scavenging properties, and the abilities to reduce hyperlipidemia, prevent lipid peroxidation, and protect the cardiovascular system. In this study, the anti-osteoarthritis (OA) effects of THSG were explored using in vitro and in vivo models. THSG inhibited nitric oxide (NO) and prostaglandin E2 (PGE2) production and inducible NO synthase (iNOS) and cyclooxygenase-2 expressions by lipopolysaccharide-stimulated RAW 264.7 cells. On the other hand, THSG inhibited PGE2 production and iNOS and matrix metalloproteinase-13 expressions by interleukin-1β-stimulated primary rat chondrocytes. Through a mono-iodoacetate-induced rat OA model assay, THSG reduced paw edema and improved the weight-bearing distribution. Therefore, THSG has anti-inflammatory activity and could be applied as a lead compound for the development as an OA drug.",
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