摘要
The widespread multidrug-resistant Enterobacteriaceae pose a serious therapeutic challenge. Colistin and tigecycline are potential antimicrobial agents for treating infections caused by extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. We evaluated the in-vitro activity of colistin sulfate against 253 ESBL producers isolated from patients admitted to a medical center in southern Taiwan (Escherichia coli, n = 82; Klebsiella pneumoniae, n = 102; Enterobacter cloacae, n = 34; and Serratia marcescens, n = 35). Colistin showed promising in-vitro activity against E. coli, K. pneumoniae, and E. cloacae, but not S. marcescens. One ESBL-producing K. pneumoniae strain with resistance to carbapenems (ertapenem, imipenem, and meropenem) was selected for time-killing studies. A combination of colistin and tigecycline showed synergism, but there was an inoculum effect. In conclusion, colistin was active against most ESBL-producing Enterobacteriaceae, and a combination of colistin with tigecycline was synergistic against some highly resistant strains, even those with carbapenem resistance.
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 699-702 |
| 頁數 | 4 |
| 期刊 | Journal of Microbiology, Immunology and Infection |
| 卷 | 48 |
| 發行號 | 6 |
| DOIs | |
| 出版狀態 | 已發佈 - 十二月 1 2015 |
指紋
ASJC Scopus subject areas
- Microbiology (medical)
- Immunology and Allergy
- Immunology and Microbiology(all)
- Infectious Diseases
引用此文
In vitro activity of colistin sulfate against Enterobacteriaceae producing extended-spectrum β-lactamases. / Ku, Yee Huang; Lee, Mei Feng; Chuang, Yin Ching; Chen, Chi Chung; Yu, Wen Liang.
於: Journal of Microbiology, Immunology and Infection, 卷 48, 編號 6, 01.12.2015, p. 699-702.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - In vitro activity of colistin sulfate against Enterobacteriaceae producing extended-spectrum β-lactamases
AU - Ku, Yee Huang
AU - Lee, Mei Feng
AU - Chuang, Yin Ching
AU - Chen, Chi Chung
AU - Yu, Wen Liang
PY - 2015/12/1
Y1 - 2015/12/1
N2 - The widespread multidrug-resistant Enterobacteriaceae pose a serious therapeutic challenge. Colistin and tigecycline are potential antimicrobial agents for treating infections caused by extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. We evaluated the in-vitro activity of colistin sulfate against 253 ESBL producers isolated from patients admitted to a medical center in southern Taiwan (Escherichia coli, n = 82; Klebsiella pneumoniae, n = 102; Enterobacter cloacae, n = 34; and Serratia marcescens, n = 35). Colistin showed promising in-vitro activity against E. coli, K. pneumoniae, and E. cloacae, but not S. marcescens. One ESBL-producing K. pneumoniae strain with resistance to carbapenems (ertapenem, imipenem, and meropenem) was selected for time-killing studies. A combination of colistin and tigecycline showed synergism, but there was an inoculum effect. In conclusion, colistin was active against most ESBL-producing Enterobacteriaceae, and a combination of colistin with tigecycline was synergistic against some highly resistant strains, even those with carbapenem resistance.
AB - The widespread multidrug-resistant Enterobacteriaceae pose a serious therapeutic challenge. Colistin and tigecycline are potential antimicrobial agents for treating infections caused by extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. We evaluated the in-vitro activity of colistin sulfate against 253 ESBL producers isolated from patients admitted to a medical center in southern Taiwan (Escherichia coli, n = 82; Klebsiella pneumoniae, n = 102; Enterobacter cloacae, n = 34; and Serratia marcescens, n = 35). Colistin showed promising in-vitro activity against E. coli, K. pneumoniae, and E. cloacae, but not S. marcescens. One ESBL-producing K. pneumoniae strain with resistance to carbapenems (ertapenem, imipenem, and meropenem) was selected for time-killing studies. A combination of colistin and tigecycline showed synergism, but there was an inoculum effect. In conclusion, colistin was active against most ESBL-producing Enterobacteriaceae, and a combination of colistin with tigecycline was synergistic against some highly resistant strains, even those with carbapenem resistance.
KW - Colistin
KW - Enterobacteriaceae
KW - ESBL
KW - Tigecycline
UR - http://www.scopus.com/inward/record.url?scp=84952870818&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84952870818&partnerID=8YFLogxK
U2 - 10.1016/j.jmii.2013.11.005
DO - 10.1016/j.jmii.2013.11.005
M3 - Article
C2 - 24388585
AN - SCOPUS:84952870818
VL - 48
SP - 699
EP - 702
JO - Journal of Microbiology, Immunology and Infection
JF - Journal of Microbiology, Immunology and Infection
SN - 0253-2662
IS - 6
ER -