摘要
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 41-52 |
| 期刊 | International Urology and Nephrology |
| 卷 | 51 |
| 發行號 | 1 |
| DOIs | |
| 出版狀態 | 已發佈 - 一月 3 2019 |
指紋
ASJC Scopus subject areas
- Nephrology
- Urology
引用此文
Improved voiding function by deep brain stimulation in traumatic brain-injured animals with bladder dysfunctions. / Praveen Rajneesh, Chellappan; Lai, Chien Hung; Chen, Shih Ching; Hsieh, Tsung Hsun; Chin, Hung Yen; Peng, Chih Wei.
於: International Urology and Nephrology, 卷 51, 編號 1, 03.01.2019, p. 41-52.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Improved voiding function by deep brain stimulation in traumatic brain-injured animals with bladder dysfunctions
AU - Praveen Rajneesh, Chellappan
AU - Lai, Chien Hung
AU - Chen, Shih Ching
AU - Hsieh, Tsung Hsun
AU - Chin, Hung Yen
AU - Peng, Chih Wei
PY - 2019/1/3
Y1 - 2019/1/3
N2 - Objective: Traumatic brain injury (TBI) is a global scenario with high mortality and disability, which does not have an effectual and approved therapy till now. Bladder dysfunction is a major symptom after TBI, and this study deals with the alleviation of bladder function in TBI rats, with the aid of deep brain stimulations (DBS). Methods: TBI was induced by weight drop model (WDM) and standardized with the experimental subjects with variable heights for weight dropping. The rats survived after TBI were considered for bladder dysfunction observations. DBS with variable stimulation parameters like cystometric analysis and MRI studies were also performed. Results: After experimental studies, TBI 2-m-height crash was determined as suitable parameter due to minimal mortality rate and significant reduction in the voiding efficiency from 67 to 28%, whereas DBS significantly reversed the value of voiding efficiency to 65–84%. MRI studies revealed the severity of TBI impact and DBS localization. Conclusion: The results showed profound therapeutic effect of PnO-DBS on voiding functions and bladder control on TBI rats.
AB - Objective: Traumatic brain injury (TBI) is a global scenario with high mortality and disability, which does not have an effectual and approved therapy till now. Bladder dysfunction is a major symptom after TBI, and this study deals with the alleviation of bladder function in TBI rats, with the aid of deep brain stimulations (DBS). Methods: TBI was induced by weight drop model (WDM) and standardized with the experimental subjects with variable heights for weight dropping. The rats survived after TBI were considered for bladder dysfunction observations. DBS with variable stimulation parameters like cystometric analysis and MRI studies were also performed. Results: After experimental studies, TBI 2-m-height crash was determined as suitable parameter due to minimal mortality rate and significant reduction in the voiding efficiency from 67 to 28%, whereas DBS significantly reversed the value of voiding efficiency to 65–84%. MRI studies revealed the severity of TBI impact and DBS localization. Conclusion: The results showed profound therapeutic effect of PnO-DBS on voiding functions and bladder control on TBI rats.
KW - Cystometric analysis
KW - Deep brain stimulations
KW - PnO
KW - Traumatic brain injury
KW - Weight drop model
UR - http://www.scopus.com/inward/record.url?scp=85057273830&partnerID=8YFLogxK
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U2 - 10.1007/s11255-018-2028-1
DO - 10.1007/s11255-018-2028-1
M3 - Article
VL - 51
SP - 41
EP - 52
JO - International Urology and Nephrology
JF - International Urology and Nephrology
SN - 0301-1623
IS - 1
ER -