Improved lung compliance following indomethacin therapy in premature infants with persistent ductus arteriosus

T. F. Yeh, A. Thalji, L. Luken, L. Lilien, I. Carr, R. S. Pildes

研究成果: 雜誌貢獻文章同行評審

29 引文 斯高帕斯(Scopus)

摘要

In the course of a double-blind controlled study of intra-venous indomethacin therapy in premature infants with patent ductus arteriosus (PDA), dynamic lung compliance (CL) was determined in 11 infants (six control, five indomethacin) who were not on assisted ventilation during the study period. The clinical, biochemical and laboratory data before the study were comparable between the groups. Following therapy with indomethacin, there was a significant decrease in left atrial/aortic root ratio (LA/Ao), left ventricular end-diastolic dimension (LVEDD) on echocardiogram, and an increase in tidal volume (V(T)) and C(L). In the control group, these variables did not change significantly. The improved lung compliance following early indomethacin closure of PDA may alter the clinical course and outcome of these premature infants.

原文英語
頁(從 - 到)698-700
頁數3
期刊Chest
80
發行號6
DOIs
出版狀態已發佈 - 一月 1 1981
對外發佈

ASJC Scopus subject areas

  • 肺和呼吸系統醫學
  • 重症監護和重症監護醫學
  • 心臟病學與心血管醫學

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