Improved bladder emptying in urinary retention by electrical stimulation of pudendal afferents

Chih Wei Peng, Jia Jin Jason Chen, Chen Li Cheng, Warren M. Grill

研究成果: 雜誌貢獻文章

30 引文 (Scopus)

摘要

Urinary retention is the inability to empty the bladder completely, and may result from bladder hypocontractility, increases in outlet resistance or both. Chronic urinary retention can lead to several urological complications and is often refractory to pharmacologic, behavioral and surgical treatments. We sought to determine whether electrical stimulation of sensory fibers in the pudendal nerve could engage an augmenting reflex and thereby improve bladder emptying in an animal model of urinary retention. We measured the efficiency of bladder emptying with and without concomitant electrical stimulation of pudendal nerve afferents in urethane-anesthetized rats. Voiding efficiency (VE = voided volume/initial volume) was reduced from 72 ± 7% to 29 ± 7% following unilateral transection of the sensory branch of the pudendal nerve (UST) and from 70 ± 5% to 18 ± 4% following bilateral transection (BST). Unilateral electrical stimulation of the proximal transected sensory pudendal nerve during distention-evoked voiding contractions significantly improved VE. Low-intensity stimulation at frequencies of 1-50 Hz increased VE to 40-51% following UST and to 39-49% following BST, while high-intensity stimulation was ineffective at increasing VE. The increase in VE was mediated by increases in the duration of distention-evoked voiding bladder contractions, rather than increases in contraction amplitude. These results are consistent with an essential role for pudendal sensory feedback in efficient bladder emptying, and raise the possibility that electrical activation of pudendal nerve afferents may provide a new approach to restore efficient bladder emptying in persons with urinary retention.

原文英語
頁(從 - 到)144-154
頁數11
期刊Journal of Neural Engineering
5
發行號2
DOIs
出版狀態已發佈 - 六月 1 2008
對外發佈Yes

指紋

Urinary Retention
Pudendal Nerve
Electric Stimulation
Urinary Bladder
Sensory feedback
Urethane
Refractory materials
Rats
Animals
Chemical activation
Fibers
Sensory Feedback
Reflex
Animal Models

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Neuroscience (miscellaneous)

引用此文

Improved bladder emptying in urinary retention by electrical stimulation of pudendal afferents. / Peng, Chih Wei; Chen, Jia Jin Jason; Cheng, Chen Li; Grill, Warren M.

於: Journal of Neural Engineering, 卷 5, 編號 2, 01.06.2008, p. 144-154.

研究成果: 雜誌貢獻文章

Peng, Chih Wei ; Chen, Jia Jin Jason ; Cheng, Chen Li ; Grill, Warren M. / Improved bladder emptying in urinary retention by electrical stimulation of pudendal afferents. 於: Journal of Neural Engineering. 2008 ; 卷 5, 編號 2. 頁 144-154.
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