Impairment of the atrial substrates by chronic cigarette smoking in patients with atrial fibrillation

Ta Chuan Tuan, Shih Lin Chang, Ching Tai Tai, Yenn Jiang Lin, Yu Feng Hu, Li Wei Lo, Wanwarang Wongcharoen, Ameya R. Udyavar, Shuo Ju Chiang, Yi Jen Chen, Hsuan Ming Tsao, Kwo Chang Ueng, Shih Ann Chen

研究成果: 雜誌貢獻文章

13 引文 斯高帕斯(Scopus)

摘要

Smoking, Voltage, and Atrial Fibrillation. Background: Smoking is a major risk factor for cardiovascular disease. The impact of smoking on the right and left atrial substrates is unknown. Methods: This study included 88 patients (age 50 ± 13 years, M/F = 71/17) who underwent four pulmonary veins isolation (PVI) for paroxysmal atrial fibrillation (AF). The mean voltage and total activation time of the individual atria were obtained by using a NavX mapping system, and were compared between the patients with and without a previous smoking history. The dose effect was evaluated by the smoking intensity-duration, defined as the number of packs per day plus how many years they had been smoking. Results: The right atrial (RA) mean voltage was lower in the patients with a previous history of smoking than in those without a history of smoking (1.92 ± 0.49 vs 2.17 ± 0.56 mV, P <0.05). The left atrial (LA) mean voltage was similar between the two groups (1.73 ± 0.67 vs 1.82 ± 0.48 mV, P = 0.488). Further, the total activation time of the RA was longer in the patients with a previous history of smoking than in those without a history of smoking, but not so for the LA. Furthermore, the voltage reduction in the RA was related to the smoking intensity-duration (Pearson's correlation, r = 0.650, P <0.001). Conclusions: In patients with atrial fibrillation, the RA mean voltage and total activation time were significantly correlated to smoking and had a dose-dependent effect.

原文英語
頁(從 - 到)259-265
頁數7
期刊Journal of Cardiovascular Electrophysiology
19
發行號3
DOIs
出版狀態已發佈 - 三月 2008
對外發佈Yes

    指紋

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

引用此

Tuan, T. C., Chang, S. L., Tai, C. T., Lin, Y. J., Hu, Y. F., Lo, L. W., Wongcharoen, W., Udyavar, A. R., Chiang, S. J., Chen, Y. J., Tsao, H. M., Ueng, K. C., & Chen, S. A. (2008). Impairment of the atrial substrates by chronic cigarette smoking in patients with atrial fibrillation. Journal of Cardiovascular Electrophysiology, 19(3), 259-265. https://doi.org/10.1111/j.1540-8167.2007.01057.x