Impaired microcirculation after subarachnoid hemorrhage in an in vivo animal model

Kuo Chuan Wang, Sung Chun Tang, Jing Er Lee, Jui Chang Tsai, Dar Ming Lai, Wei Chou Lin, Chih Peng Lin, Yong-Kwang Tu, Sung Tsang Hsieh

研究成果: 雜誌貢獻文章

2 引文 (Scopus)

摘要

The influence of aneurysmal subarachnoid hemorrhage (SAH) on brain microcirculation has not yet been systematically investigated. We established an animal model to examine (1) the brain surface microcirculation (2) the influences of cerebrospinal fluid (CSF) from aneurysmal SAH on the brain surface microcirculation. A rat SAH model was induced by injection of autologous arterial blood into the cisterna magnum, and the brain surface microcirculation was evaluated by a capillary videoscope with craniotomy at the fronto-parietal region. CSF from SAH rats and SAH patients was applied on the brain surface of naïve rats to assess the resulting microcirculatory changes. In the SAH rats, diffuse constriction of cortical arterioles within 24 hours of SAH was observed. Similar patterns of microcirculation impairment were induced on normal rat brain surfaces via application of CSF from SAH rats and SAH patients. Furthermore, the proportion of subjects with arteriolar vasoconstriction was significantly higher in the group of SAH patients with delayed ischemic neurological deficits (DIND) than in those without DIND (p < 0.001). This study demonstrated impaired microcirculation on brain surface arterioles in a rat model of SAH. CSF from SAH rats and patients was responsible for impairment of brain surface microcirculation.

原文英語
文章編號13315
期刊Scientific Reports
8
發行號1
DOIs
出版狀態已發佈 - 十二月 1 2018

指紋

Subarachnoid Hemorrhage
Microcirculation
Animal Models
Brain
Cerebrospinal Fluid
Arterioles
Parietal Lobe
Craniotomy
Vasoconstriction
Constriction

ASJC Scopus subject areas

  • General

引用此文

Wang, K. C., Tang, S. C., Lee, J. E., Tsai, J. C., Lai, D. M., Lin, W. C., ... Hsieh, S. T. (2018). Impaired microcirculation after subarachnoid hemorrhage in an in vivo animal model. Scientific Reports, 8(1), [13315]. https://doi.org/10.1038/s41598-018-31709-7

Impaired microcirculation after subarachnoid hemorrhage in an in vivo animal model. / Wang, Kuo Chuan; Tang, Sung Chun; Lee, Jing Er; Tsai, Jui Chang; Lai, Dar Ming; Lin, Wei Chou; Lin, Chih Peng; Tu, Yong-Kwang; Hsieh, Sung Tsang.

於: Scientific Reports, 卷 8, 編號 1, 13315, 01.12.2018.

研究成果: 雜誌貢獻文章

Wang, KC, Tang, SC, Lee, JE, Tsai, JC, Lai, DM, Lin, WC, Lin, CP, Tu, Y-K & Hsieh, ST 2018, 'Impaired microcirculation after subarachnoid hemorrhage in an in vivo animal model', Scientific Reports, 卷 8, 編號 1, 13315. https://doi.org/10.1038/s41598-018-31709-7
Wang, Kuo Chuan ; Tang, Sung Chun ; Lee, Jing Er ; Tsai, Jui Chang ; Lai, Dar Ming ; Lin, Wei Chou ; Lin, Chih Peng ; Tu, Yong-Kwang ; Hsieh, Sung Tsang. / Impaired microcirculation after subarachnoid hemorrhage in an in vivo animal model. 於: Scientific Reports. 2018 ; 卷 8, 編號 1.
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