Impact of second primary esophageal or lung cancer on survival of patients with head and neck cancer

Min Chi Chen, Wei Chao Huang, Chunghuang Hubert Chan, Ping Tsung Chen, Kuan Der Lee

研究成果: 雜誌貢獻文章同行評審

38 引文 斯高帕斯(Scopus)

摘要

Second cancers following head and neck cancer (HNC) most often involve the esophagus and lung, yet the actual magnitude of impact of second primary esophageal or lung cancer on survival of HNC patients has not been well established, particularly by a large-scale epidemiological study. To provide a quantitative estimate of the survival impact, we conducted a population-based study including 63,720 cases of HNC subsets, of which 3658 developed at least one second primary malignancy, 253 had a second esophageal cancer and 388 had a second lung cancer. A Cox proportional hazards model which included age at initial cancer diagnosis and gender were employed to compare the survival rates between patients with different types of second cancers. Our results showed that the second esophageal or lung cancer contributed to a poorer outcome than the other types of second cancer, regardless of the index tumor site (all Ps ≤ 0.019). The overall median survival was 0.76 ± 0.04 and 0.72 ± 0.08 years for second esophageal and lung cancers, respectively. Compared to those without second cancers, the patients with second esophageal or lung cancer were associated with a significant reduction in survival, with an estimated 31-105% excess risk of death according to the site of the primary index tumor. In conclusion, the second esophageal and lung cancers have a significantly negative impact on the survival of HNC patients, thereby calling for a more effective program for surveillance and chemoprevention for these two sites.
原文英語
頁(從 - 到)249-254
頁數6
期刊Oral Oncology
46
發行號4
DOIs
出版狀態已發佈 - 四月 2010
對外發佈

ASJC Scopus subject areas

  • 腫瘤科
  • 口腔外科
  • 癌症研究

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