Impact of radiotherapy for pediatric CNS atypical teratoid/rhabdoid tumor (single institute experience)

Yi Wei Chen, Tai Tong Wong, Donald Ming Tak Ho, Pin I. Huang, Kai Ping Chang, Cheng Ying Shiau, Sang Hue Yen

研究成果: 雜誌貢獻文章同行評審

100 引文 斯高帕斯(Scopus)

摘要

Purpose: To assess outcomes and prognostic factors in radiotherapy of pediatric central nervous system atypical teratoid/rhabdoid tumor (AT/RT). Methods and Materials: Seventeen patients with central nervous system AT/RT were retrospectively reviewed after curative radiotherapy as primary or adjuvant therapy between January 1990 and December 2003. Overall and failure-free survival rates were calculated using the Kaplan-Meier method. The log-rank method was used to compare the effects of dosage (>50 Gy or ≤50 Gy) and treatment duration (>45 days or ≤45 days). Multivariate analysis was performed for prognostic factors. Results: Median overall survival and failure-free survival were 17 and 11 months, respectively. The 3 longest-surviving patients were older, underwent gross tumor removal, and completed both craniospinal and focal boost irradiation. Multivariate analysis revealed a significant relationship between the following: overall survival and performance status (p = 0.019), failure-free survival and total irradiation dose (p = 0.037), time interval between surgery and radiotherapy initiation (p = 0.031), and time interval between surgery and radiotherapy end point (p = 0.047). Conclusion: Radiotherapy is crucial in the treatment of AT/RT. We recommend initiating radiotherapy immediately postoperatively and before systemic chemotherapy in pediatric patients ≥3 years of age.

原文英語
頁(從 - 到)1038-1043
頁數6
期刊International Journal of Radiation Oncology Biology Physics
64
發行號4
DOIs
出版狀態已發佈 - 三月 15 2006
對外發佈

ASJC Scopus subject areas

  • 輻射
  • 腫瘤科
  • 放射學、核子醫學和影像學
  • 癌症研究

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