摘要
原文 | 英語 |
---|---|
文章編號 | 1304 |
期刊 | Nutrients |
卷 | 11 |
發行號 | 6 |
DOIs | |
出版狀態 | 已發佈 - 六月 1 2019 |
指紋
ASJC Scopus subject areas
- Food Science
- Nutrition and Dietetics
引用此文
Impact of Percent Body Fat on All-Cause Mortality among Adequate Dialysis Patients with and without Insulin Resistance : A Multi-Center Prospective Cohort Study. / Duong, Tuyen Van; Wong, Te Chih; Chen, Hsi Hsien; Chen, Tso Hsiao; Hsu, Yung Ho; Peng, Sheng Jeng; Kuo, Ko Lin; Liu, Hsiang Chung; Lin, En Tzu; Yang, Shwu Huey.
於: Nutrients, 卷 11, 編號 6, 1304, 01.06.2019.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Impact of Percent Body Fat on All-Cause Mortality among Adequate Dialysis Patients with and without Insulin Resistance
T2 - A Multi-Center Prospective Cohort Study
AU - Duong, Tuyen Van
AU - Wong, Te Chih
AU - Chen, Hsi Hsien
AU - Chen, Tso Hsiao
AU - Hsu, Yung Ho
AU - Peng, Sheng Jeng
AU - Kuo, Ko Lin
AU - Liu, Hsiang Chung
AU - Lin, En Tzu
AU - Yang, Shwu Huey
PY - 2019/6/1
Y1 - 2019/6/1
N2 - The association between body fat and mortality in hemodialysis patients remains controversial. We examined the effect of percent body fat (PBF) on all-cause mortality among adequate hemodialysis patients with and without insulin resistance (IR). A prospective cohort study was conducted on 365 adequate hemodialysis patients (equilibrated Kt/V ≥ 1.2) from seven hospitals. Patients' characteristics and clinical and biochemical parameters were assessed at baseline between September 2013 and April 2017. Patients were followed up for all-cause mortality until April 2018. The median value of homeostatic model assessment (HOMA-IR) was used to classify IR. Cox proportional hazard models were utilized to examine predictors of all-cause mortality. During 1.4 (1.0-3.2) years of follow-up, 46 patients died. In patients with IR (HOMA-IR ≥ 5.18), PBF was significantly higher in the survival group than in the death group (31.3 ± 9.0 vs. 25.4 ± 8.2, p = 0.005). After controlling for confounding factors, PBF was significantly associated with lower risk for all-cause mortality in patients with IR (hazard ratio, 0.94; 95% confidence interval, 0.89-1.00; p = 0.033). The association was not observed in patients without IR. In conclusion, percent body fat shows a protective effect on survival in hemodialysis patients with IR.
AB - The association between body fat and mortality in hemodialysis patients remains controversial. We examined the effect of percent body fat (PBF) on all-cause mortality among adequate hemodialysis patients with and without insulin resistance (IR). A prospective cohort study was conducted on 365 adequate hemodialysis patients (equilibrated Kt/V ≥ 1.2) from seven hospitals. Patients' characteristics and clinical and biochemical parameters were assessed at baseline between September 2013 and April 2017. Patients were followed up for all-cause mortality until April 2018. The median value of homeostatic model assessment (HOMA-IR) was used to classify IR. Cox proportional hazard models were utilized to examine predictors of all-cause mortality. During 1.4 (1.0-3.2) years of follow-up, 46 patients died. In patients with IR (HOMA-IR ≥ 5.18), PBF was significantly higher in the survival group than in the death group (31.3 ± 9.0 vs. 25.4 ± 8.2, p = 0.005). After controlling for confounding factors, PBF was significantly associated with lower risk for all-cause mortality in patients with IR (hazard ratio, 0.94; 95% confidence interval, 0.89-1.00; p = 0.033). The association was not observed in patients without IR. In conclusion, percent body fat shows a protective effect on survival in hemodialysis patients with IR.
KW - All-cause mortality
KW - Dialysis adequacy
KW - HOMA-IR
KW - Hemodialysis
KW - Insulin resistance
KW - Mortality
KW - Multi-center
KW - Obesity
KW - Percent body fat
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=85067830451&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067830451&partnerID=8YFLogxK
U2 - 10.3390/nu11061304
DO - 10.3390/nu11061304
M3 - Article
C2 - 31181824
AN - SCOPUS:85067830451
VL - 11
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 6
M1 - 1304
ER -