Impact of metabolic syndrome components on incident stroke subtypes: A Chinese cohort study

Y. C. Chen, C. A. Sun, T. Yang, C. H. Chu, C. H. Bai, S. L. You, L. C. Hwang, C. H. Chen, C. Y. Wei, Y. C. Chou

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

摘要

Limited evidence is available on the risk differences in the development of stroke subtypes in relation to particular clustering patterns of the metabolic syndrome (MetS) components. A follow-up study of a Chinese cohort involving 10 292 individuals was performed to assess the roles of cluster patterns of the MetS components in the prediction of incident stroke subtypes. During follow-up, there were 161 incident cases of ischemic strokes and 41 incident cases of hemorrhagic strokes. Among MetS components, only the hypertensive trait was associated with significantly elevated risks of both ischemic and hemorrhagic strokes. Furthermore, MetS with hypertension as components was associated with increased risk of ischemic and hemorrhagic strokes (adjusted hazards ratio (95% confidence interval) was 2.96 (1.94-4.50) and 2.93 (1.25-6.90), respectively) as compared with those who had neither hypertension nor MetS. Notably, as the number of the MetS components increased, the risk of ischemic stroke significantly and dose-dependently increased. This implies a cumulative effect of MetS components in elevating the risk of ischemic stroke. These findings suggest that MetS comprises heterogenous clusters with respect to the risk of developing the subtype of stroke.

原文英語
頁(從 - 到)689-693
頁數5
期刊Journal of Human Hypertension
28
發行號11
DOIs
出版狀態已發佈 - 一月 1 2014

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine(all)

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    Chen, Y. C., Sun, C. A., Yang, T., Chu, C. H., Bai, C. H., You, S. L., Hwang, L. C., Chen, C. H., Wei, C. Y., & Chou, Y. C. (2014). Impact of metabolic syndrome components on incident stroke subtypes: A Chinese cohort study. Journal of Human Hypertension, 28(11), 689-693. https://doi.org/10.1038/jhh.2013.152