Impact of circulating monocyte CD36 level on atrial fibrillation and subsequent catheter ablation

Yu Feng Hu, Hung I. Yeh, Hsuan Ming Tsao, Ching Tai Tai, Yenn Jiang Lin, Shih Lin Chang, Li Wei Lo, Ta Chuan Tuan, Cheng Hwai Tzeng, Sung Hao Huang, Yung Kuo Lin, Shih Ann Chen

研究成果: 雜誌貢獻文章同行評審

18 引文 斯高帕斯(Scopus)

摘要

Background: Inflammation, an important mechanism in the pathogenesis of atrial fibrillation (AF), can be regulated by CD36 in monocytes. Objective: The purpose of this study was to test the hypothesis that CD36 in monocytes contributes to the pathogenesis of AF. Methods: A prospective study that enrolled 87 patients with AF and 70 without AF was conducted. Results: Compared to patients without AF, patients with AF had monocytes with a lower level of CD36 protein, which correlated with left atrial diameter, left atrial emptying fraction, and left atrial mean voltage. In AF patients after catheter ablation, Kaplan-Meier analysis showed that the sinus rhythm maintenance rate was higher in patients with high CD36 levels. Low CD36 level was an independent predictor of recurrence. After successful ablation, the CD36 level increased by 57%, reaching that of control patients. CD36 level was not correlated with the level of high-sensitivity C-reactive protein. Analysis of mRNA levels from a buffy coat revealed that AF patients had lower CD36 and interleukin-10 levels and higher peroxisome proliferator-activated receptor-γ and tumor necrosis factor-α levels, with CD36 level positively correlated with interleukin-10 level but inversely correlated with peroxisome proliferator-activated receptor-γ and tumor necrosis factor-α levels. Conclusion: Low CD36 levels in circulating monocytes were associated with AF occurrence and predicted recurrence after catheter ablation. The link between CD36 and AF identified a novel AF-related inflammatory pathway.

原文英語
頁(從 - 到)650-656
頁數7
期刊Heart Rhythm
8
發行號5
DOIs
出版狀態已發佈 - 五月 2011

ASJC Scopus subject areas

  • 心臟病學與心血管醫學
  • 生理學(醫學)

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