Immunosuppressive roles of galectin-1 in the tumor microenvironment

Yanyu Huang, Hsiao Chi Wang, Junwei Zhao, Ming Heng Wu, Tsung Chieh Shih

研究成果: 雜誌貢獻回顧型文獻同行評審

1 引文 斯高帕斯(Scopus)

摘要

Evasion of immune surveillance is an accepted hallmark of tumor progression. The production of immune suppressive mediators by tumor cells is one of the major mechanisms of tumor immune escape. Galectin-1 (Gal-1), a pivotal immunosuppressive molecule, is expressed by many types of cancer. Tumor-secreted Gal-1 can bind to glycosylated receptors on immune cells and trigger the suppression of immune cell function in the tumor microenvironment, contributing to the immune evasion of tumors. The aim of this review is to summarize the current literature on the expression and function of Gal-1 in the human tumor microenvironment, as well as therapeutics targeting Gal-1.

原文英語
文章編號1398
期刊Biomolecules
11
發行號10
DOIs
出版狀態已發佈 - 10月 2021

ASJC Scopus subject areas

  • 生物化學
  • 分子生物學

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