Imaging reactive oxygen species dynamics in living cells and tissues

Chau Chung Wu, Yen Bin Liu, Long Sheng Lu, Chii Wann Lin

研究成果: 雜誌貢獻文章

4 引文 斯高帕斯(Scopus)

摘要

Reactive oxygen species (ROS) can mediate cellular signal transduction, destroy hazardous foreign pathogens, regulate transcriptional activities and therefore are essential in normal cellular physiology. On the other hand, inadequate control of ROS production can induce peroxidation of essential biomolecules and result in cellular dysfunction. In the worst condition even cell death ensues. Therefore, they have great implications in the initiation and progression of numerous diseases. Chemical instability of ROS limits its direct detection and the dynamics remain poorly studied. To study the ROS dynamics, the endogenous or exogenous redox-sensitive fluorophores provide a good chance to detect the real-time changes in in vivo or in vitro settings. Here these methods are reviewed and their potential applications are discussed.

原文英語
頁(從 - 到)39-44
頁數6
期刊Frontiers in Bioscience - Scholar
1 S
發行號1
出版狀態已發佈 - 一月 6 2009
對外發佈Yes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

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