IL-6-transfected tumor cells modulate the status of CD8+ and CD4+ T cells to control tumor growth

Chia Ling Hsieh, Shih Jen Liu, Chia Rui Shen, Mei Yu Chen, Shu Ching Hsu, Jy Ping Tsai, Yi Shiuan Li, Ching Jen Yang, Pele Chong, Hsin Wei Chen

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5 引文 斯高帕斯(Scopus)

摘要

IL-6 is a proinflammatory cytokine secreted by tumor cells and immune cells to affect the development of cancer. This study demonstrates the effects of tumor-derived IL-6 on the malignancy of tumor cells and tumor immunity. The tumor cell line, EG7, was transfected with a mammalian expression vector encoding the full length of murine IL-6 to mimic IL-6-secreting tumor cells. Two IL-6 transfectants with low and high IL-6 production were compared in vitro and in vivo. While the in vitro proliferation rates of both transfectants and the parental line were similar, high expression of IL-6 induced a significant reduction in tumor growth in vivo. Concomitantly, there was an increase in IFN-γ positive tumor-infiltrating lymphocytes and a decrease in the suppressive CD4+CD25+FoxP3+ population. These results demonstrate the direct effects of tumor-derived IL-6 on cancer development and the induction of tumor immunity.
原文英語
頁(從 - 到)486-491
頁數6
期刊Immunobiology
215
發行號6
DOIs
出版狀態已發佈 - 六月 2010
對外發佈

ASJC Scopus subject areas

  • 免疫學和過敏
  • 免疫學
  • 血液學

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