IL-17 cytokine family

Mio Kawaguchi, Mitsuru Adachi, Naruhito Oda, Fumio Kokubu, Shau Ku Huang

研究成果: 雜誌貢獻回顧型文獻同行評審

280 引文 斯高帕斯(Scopus)

摘要

A new family of cytokines, IL-17, has recently been defined that reveals a distinct ligand-receptor signaling system. Functional studies have provided evidence for its importance in the regulation of immune responses. Notably, 3 members, IL-17A, IL-17E (IL-25), and IL-17F, have been best characterized both in vitro and in vivo, and have been shown to be proinflammatory in nature. This proinflammatory activity is exemplified by their involvement in pulmonary inflammatory responses, in which both IL-17A and IL-17F are involved in the recruitment of neutrophils, and IL-17E is able to induce T H2 cytokine production and eosinophilia. Although the elucidation of a detailed mechanism of action continues to be an active area of research, the potent inflammatory activity and its association with various human disease states suggest this new cytokine family as an important contributor to the pathophysiology of human disease conditions, in particular the pulmonary diseases.

原文英語
頁(從 - 到)1265-1273
頁數9
期刊Journal of Allergy and Clinical Immunology
114
發行號6
DOIs
出版狀態已發佈 - 12月 2004
對外發佈

ASJC Scopus subject areas

  • 免疫學和過敏
  • 免疫學

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