IGF1 gene is associated with triglyceride levels in subjects with family history of hypertension from the SAPPHIRe and TWB projects

Wen Chang Wang, Yen Feng Chiu, Ren Hua Chung, Chii Min Hwu, I. Te Lee, Chien Hsing Lee, Yi Cheng Chang, Kuan Yi Hung, Thomas Quertermous, Yii Der I. Chen, Chao A. Hsiung

研究成果: 雜誌貢獻文章

摘要

Chromosome 12q23-q24 has been linked to triglyceride (TG) levels by previous linkage studies, and it contains the Insulin-like growth factor 1 (IGF1) gene. We investigated the association between IGF1 and TG levels using two independent samples collected in Taiwan. First, based on 954 siblings in 397 families from the Stanford Asian Pacific Program in Hypertension and Insulin Resistance (SAPPHIRe), we found that rs978458 was associated with TG levels (β = -0.049, p = 0.0043) under a recessive genetic model. Specifically, subjects carrying the homozygous genotype of the minor allele had lower TG levels, compared with other subjects. Then, a series of stratification analyses in a large sample of 13,193 unrelated subjects from the Taiwan biobank (TWB) project showed that this association appeared in subjects with a family history (FH) of hypertension (β = -0.045, p = 0.0000034), but not in subjects without such an FH. A re-examination of the SAPPHIRe sample confirmed that this association appeared in subjects with an FH of hypertension (β = -0.068, p = 0.0025), but not in subjects without an FH. The successful replication in two independent samples indicated that IGF1 is associated with TG levels in subjects with an FH of hypertension in Taiwan.
原文英語
頁(從 - 到)1035-1042
頁數8
期刊International Journal of Medical Sciences
15
發行號10
DOIs
出版狀態已發佈 - 六月 14 2018

指紋

Somatomedins
Taiwan
Insulin Resistance
Triglycerides
Hypertension
Genes
Genetic Models
Siblings
Chromosomes
Alleles
Genotype

ASJC Scopus subject areas

  • Medicine(all)

引用此文

IGF1 gene is associated with triglyceride levels in subjects with family history of hypertension from the SAPPHIRe and TWB projects. / Wang, Wen Chang; Chiu, Yen Feng; Chung, Ren Hua; Hwu, Chii Min; Lee, I. Te; Lee, Chien Hsing; Chang, Yi Cheng; Hung, Kuan Yi; Quertermous, Thomas; Chen, Yii Der I.; Hsiung, Chao A.

於: International Journal of Medical Sciences, 卷 15, 編號 10, 14.06.2018, p. 1035-1042.

研究成果: 雜誌貢獻文章

Wang, WC, Chiu, YF, Chung, RH, Hwu, CM, Lee, IT, Lee, CH, Chang, YC, Hung, KY, Quertermous, T, Chen, YDI & Hsiung, CA 2018, 'IGF1 gene is associated with triglyceride levels in subjects with family history of hypertension from the SAPPHIRe and TWB projects', International Journal of Medical Sciences, 卷 15, 編號 10, 頁 1035-1042. https://doi.org/10.7150/ijms.25742
Wang, Wen Chang ; Chiu, Yen Feng ; Chung, Ren Hua ; Hwu, Chii Min ; Lee, I. Te ; Lee, Chien Hsing ; Chang, Yi Cheng ; Hung, Kuan Yi ; Quertermous, Thomas ; Chen, Yii Der I. ; Hsiung, Chao A. / IGF1 gene is associated with triglyceride levels in subjects with family history of hypertension from the SAPPHIRe and TWB projects. 於: International Journal of Medical Sciences. 2018 ; 卷 15, 編號 10. 頁 1035-1042.
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abstract = "Chromosome 12q23-q24 has been linked to triglyceride (TG) levels by previous linkage studies, and it contains the Insulin-like growth factor 1 (IGF1) gene. We investigated the association between IGF1 and TG levels using two independent samples collected in Taiwan. First, based on 954 siblings in 397 families from the Stanford Asian Pacific Program in Hypertension and Insulin Resistance (SAPPHIRe), we found that rs978458 was associated with TG levels (β =-0.049, p = 0.0043) under a recessive genetic model. Specifically, subjects carrying the homozygous genotype of the minor allele had lower TG levels, compared with other subjects. Then, a series of stratification analyses in a large sample of 13,193 unrelated subjects from the Taiwan biobank (TWB) project showed that this association appeared in subjects with a family history (FH) of hypertension (β =-0.045, p = 0.0000034), but not in subjects without such an FH. A re-examination of the SAPPHIRe sample confirmed that this association appeared in subjects with an FH of hypertension (β =-0.068, p = 0.0025), but not in subjects without an FH. The successful replication in two independent samples indicated that IGF1 is associated with TG levels in subjects with an FH of hypertension in Taiwan.",
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T1 - IGF1 gene is associated with triglyceride levels in subjects with family history of hypertension from the SAPPHIRe and TWB projects

AU - Wang, Wen Chang

AU - Chiu, Yen Feng

AU - Chung, Ren Hua

AU - Hwu, Chii Min

AU - Lee, I. Te

AU - Lee, Chien Hsing

AU - Chang, Yi Cheng

AU - Hung, Kuan Yi

AU - Quertermous, Thomas

AU - Chen, Yii Der I.

AU - Hsiung, Chao A.

PY - 2018/6/14

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N2 - Chromosome 12q23-q24 has been linked to triglyceride (TG) levels by previous linkage studies, and it contains the Insulin-like growth factor 1 (IGF1) gene. We investigated the association between IGF1 and TG levels using two independent samples collected in Taiwan. First, based on 954 siblings in 397 families from the Stanford Asian Pacific Program in Hypertension and Insulin Resistance (SAPPHIRe), we found that rs978458 was associated with TG levels (β =-0.049, p = 0.0043) under a recessive genetic model. Specifically, subjects carrying the homozygous genotype of the minor allele had lower TG levels, compared with other subjects. Then, a series of stratification analyses in a large sample of 13,193 unrelated subjects from the Taiwan biobank (TWB) project showed that this association appeared in subjects with a family history (FH) of hypertension (β =-0.045, p = 0.0000034), but not in subjects without such an FH. A re-examination of the SAPPHIRe sample confirmed that this association appeared in subjects with an FH of hypertension (β =-0.068, p = 0.0025), but not in subjects without an FH. The successful replication in two independent samples indicated that IGF1 is associated with TG levels in subjects with an FH of hypertension in Taiwan.

AB - Chromosome 12q23-q24 has been linked to triglyceride (TG) levels by previous linkage studies, and it contains the Insulin-like growth factor 1 (IGF1) gene. We investigated the association between IGF1 and TG levels using two independent samples collected in Taiwan. First, based on 954 siblings in 397 families from the Stanford Asian Pacific Program in Hypertension and Insulin Resistance (SAPPHIRe), we found that rs978458 was associated with TG levels (β =-0.049, p = 0.0043) under a recessive genetic model. Specifically, subjects carrying the homozygous genotype of the minor allele had lower TG levels, compared with other subjects. Then, a series of stratification analyses in a large sample of 13,193 unrelated subjects from the Taiwan biobank (TWB) project showed that this association appeared in subjects with a family history (FH) of hypertension (β =-0.045, p = 0.0000034), but not in subjects without such an FH. A re-examination of the SAPPHIRe sample confirmed that this association appeared in subjects with an FH of hypertension (β =-0.068, p = 0.0025), but not in subjects without an FH. The successful replication in two independent samples indicated that IGF1 is associated with TG levels in subjects with an FH of hypertension in Taiwan.

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