IGF-I secretion by prostate carcinoma cells does not alter tumor-bone cell interactions in vitro or in vivo

Janet Rubin, Xian Fan, Jill Rahnert, Buer Sen, Chia Ling Hsieh, Tamara C. Murphy, Mark S. Nanes, Lindsay G. Horton, Wesley G. Beamer, Clifford J. Rosen

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16 引文 斯高帕斯(Scopus)

摘要

BACKGROUND. IGF-I is an important growth and differentiative factor for osteoblasts and may have a role in defining prostate cancer risk and skeletal metastases. METHODS. Conditioned media (CM) from human prostate cancer (PC), C4-2 and C4-2B, which produce osteoblastic lesions, and PC-3, which causes osteolysis, was added to MC3T3-E1 bone cultures. SCID mice were injected intratibially with these engineered cells. Tumor bearing tibiae were analyzed by microCT and pQCT. RESULTS. CM from PC cells increased osteoblast proliferation and differentiation and was unaltered by the type of PC cell, IGF-I antibodies, or exogenous IGF-I and IGFBP2. Study of intratibial PC tumors in SCID mice showed that C4-2 cells grew slowly preserving bone structure, while PC-3 tumors caused rapid osteolysis. Overexpression of IGF-I did not change either tumor progression or skeletal response. CONCLUSIONS. IGF-I is neither necessary nor sufficient for the osteoblastic response to PC metastases.
原文英語
頁(從 - 到)789-800
頁數12
期刊Prostate
66
發行號8
DOIs
出版狀態已發佈 - 六月 1 2006
對外發佈Yes

ASJC Scopus subject areas

  • Oncology
  • Urology

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