Identifying cancer highly-expressed membrane receptors for targeted drug delivery

Wei Chih Huang, Feng Mao Lin, Tzu Hao Chang, Kuang Wen Liao, Hsien Da Huang

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

摘要

Currently, the accompanying side effects of anti-cancer drugs owing to incorrect delivery to normal tissues should be reduced. We present a database (MRTDD) with identified cancer highly-expressed membrane receptors (CHMRs) which can be used in targeted drug delivery. To evaluate the probability of occurrence of incorrect delivery, we calculate tissue index for each CHMR and expect to identify good candidates. The information provided includes: (1) genomic annotations; (2) gene expression profiles of membrane receptors in cancer tissue vs. corresponding normal tissue, normal tissues of body and cancer cell-lines; (3) available antibody services of manufacturers. MRTDD is available at http://mrtdd.mbc.nctu.edu.tw/.

原文英語
頁(從 - 到)192-209
頁數18
期刊International Journal of Bioinformatics Research and Applications
8
發行號3-4
DOIs
出版狀態已發佈 - 九月 2012
對外發佈Yes

ASJC Scopus subject areas

  • Health Informatics
  • Health Information Management
  • Biomedical Engineering
  • Clinical Biochemistry

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