Identification of two novel HLA-A*02 variants, A*02

319 and A*02:01:64, in two Taiwanese marrow stem cell donors by sequence-based typing

K. L. Yang, S. K. Lee, S. Y. Yang, R. H. Kao, C. L. Lin, P. Y. Lin

研究成果: 雜誌貢獻文章

3 引文 (Scopus)

摘要

We report here two novel variants of HLA-A*02 allele, A*02:319 and A*02:01:64, discovered in two Taiwanese unrelated volunteer bone marrow donors by sequence-based typing (SBT) method. The DNA sequence of A*02:319 is identical to A*02:07 in exons 2 and 3 but varies with one nucleotide at codon 9 (TTC->TCC). The variation caused one amino acid substitution at residue 9 (F->S). On the other hand, the DNA sequence of A*02:01:64 is identical to the sequence of A*02:01:01:01 in exons 2 and 3 except a silent mutation at codon 114 (CAC->CAT). The probable HLA-A, HLA-B and HLA-DRB1 haplotypes in association with A*02:319 and A*02:01:64 were deduced as A*02:319-B*46:01-DRB1*04 and A*02:01:64-B*38:02-DRB1*16:02, respectively.
原文英語
頁(從 - 到)261-263
頁數3
期刊International Journal of Immunogenetics
39
發行號3
DOIs
出版狀態已發佈 - 六月 1 2012
對外發佈Yes

指紋

HLA-A Antigens
Codon
Exons
Stem Cells
Bone Marrow
Tissue Donors
HLA-DRB1 Chains
HLA-B Antigens
Amino Acid Substitution
Haplotypes
Volunteers
Nucleotides
Alleles
Silent Mutation

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

引用此文

Identification of two novel HLA-A*02 variants, A*02 : 319 and A*02:01:64, in two Taiwanese marrow stem cell donors by sequence-based typing. / Yang, K. L.; Lee, S. K.; Yang, S. Y.; Kao, R. H.; Lin, C. L.; Lin, P. Y.

於: International Journal of Immunogenetics, 卷 39, 編號 3, 01.06.2012, p. 261-263.

研究成果: 雜誌貢獻文章

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abstract = "We report here two novel variants of HLA-A*02 allele, A*02:319 and A*02:01:64, discovered in two Taiwanese unrelated volunteer bone marrow donors by sequence-based typing (SBT) method. The DNA sequence of A*02:319 is identical to A*02:07 in exons 2 and 3 but varies with one nucleotide at codon 9 (TTC->TCC). The variation caused one amino acid substitution at residue 9 (F->S). On the other hand, the DNA sequence of A*02:01:64 is identical to the sequence of A*02:01:01:01 in exons 2 and 3 except a silent mutation at codon 114 (CAC->CAT). The probable HLA-A, HLA-B and HLA-DRB1 haplotypes in association with A*02:319 and A*02:01:64 were deduced as A*02:319-B*46:01-DRB1*04 and A*02:01:64-B*38:02-DRB1*16:02, respectively.",
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AU - Lin, P. Y.

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